Research Centres (26996)

Clinical Trials Unit (455) Month Authors/Creators Item Type Full Text

March 2019

Collecting and exploiting data to understand a nation's sexual health needs: Implications for the British National Surveys of Sexual Attitudes and Lifestyles (Natsal). (2018) Mercer, Catherine H; Clifton, Soazig; Prior, Gillian; Aldridge, Robert W; Bonell, Chris; Copas, Andrew J; Field, Nigel; Gibbs, Jo; Macdowall, Wendy; Mitchell, Kirstin R; Tanton, Clare; Thomson, Nick; Unemo, Magnus; Sonnenberg, Pam

February 2019

Derivation and Validation of a Chronic Total Coronary Occlusion Intervention Procedural Success Score From the 20,000-Patient EuroCTO Registry: The EuroCTO (CASTLE) Score. (2018) Szijgyarto, Zsolt; Rampat, Rajiv; Werner, Gerald S; Ho, Claudius; Reifart, Nicolaus; Lefevre, Thierry; Louvard, Yves; Avran, Alexandre; Kambis, Mashayekhi; Buettner, Heinz-Joachim; Di Mario, Carlo; Gershlick, Anthony; Escaned, Javier; Sianos, George; Galassi, Alfredo; Garbo, Roberto; Goktekin, Omer; Meyer-Gessner, Marcus; Lauer, Bernward; Elhadad, Simon; Bufe, Alexander; Boudou, Nicolas; Sievert, Horst; Martin-Yuste, Victoria; Thuesen, Leif; Erglis, Andrejs; Christiansen, Evald; Spratt, James; Bryniarski, Lesciak; Clayton, Tim; Hildick-Smith, David

Cross-sectional analysis of chemsex drug use and gonorrhoea diagnosis among men who have sex with men in the UK. (2018) Kohli, Manik; Hickson, Ford; Free, Caroline; Reid, David; Weatherburn, Peter description

December 2018

Tranexamic acid for the prevention of postpartum bleeding in women with anaemia: study protocol for an international, randomised, double-blind, placebo-controlled trial. (2018) Ker, Katharine; Roberts, Ian; Chaudhri, Rizwana; Fawole, Bukola; Beaumont, Danielle; Balogun, Eni; Prowse, Danielle; Pepple, Tracey; Javaid, Kiran; Kayani, Aasia; Arulkumaran, Sabaratnam; Bates, Imelda; Shakur-Still, Haleema; WOMAN-2 trial collaborators

What concentration of tranexamic acid is needed to inhibit fibrinolysis? A systematic review of pharmacodynamics studies. (2018) Picetti, Roberto; Shakur-Still, Haleema; Medcalf, Robert L; Standing, Joseph F; Roberts, Ian

Interventions integrating health and academic interventions to prevent substance use and violence: a systematic review and synthesis of process evaluations. (2018) Tancred, Tara; Paparini, Sara; Melendez-Torres, GJ; Fletcher, Adam; Thomas, James; Campbell, Rona; Bonell, Chris

Health impacts of parental migration on left-behind children and adolescents: a systematic review and meta-analysis. (2018) Fellmeth, Gracia; Rose-Clarke, Kelly; Zhao, Chenyue; Busert, Laura K; Zheng, Yunting; Massazza, Alessandro; Sonmez, Hacer; Eder, Ben; Blewitt, Alice; Lertgrai, Wachiraya; Orcutt, Miriam; Ricci, Katharina; Mohamed-Ahmed, Olaa; Burns, Rachel; Knipe, Duleeka; Hargreaves, Sally; Hesketh, Therese; Opondo, Charles; Devakumar, Delan

November 2018

Bias due to MEasurement Reactions In Trials to improve health (MERIT): protocol for research to develop MRC guidance. (2018) Miles, Lisa M; Elbourne, Diana; Farmer, Andrew; Gulliford, Martin; Locock, Louise; McCambridge, Jim; Sutton, Stephen; French, David P

Predictors of postabortion contraception use in Cambodia. (2018) Adelman, Sara; Free, Caroline; Smith, Chris

Effects of the Learning Together intervention on bullying and aggression in English secondary schools (INCLUSIVE): a cluster randomised controlled trial. (2018) Bonell, Chris; Allen, Elizabeth; Warren, Emily; McGowan, Jennifer; Bevilacqua, Leonardo; Jamal, Farah; Legood, Rosa; Wiggins, Meg; Opondo, Charles; Mathiot, Anne; Sturgess, Jo; Fletcher, Adam; Sadique, Zia; Elbourne, Diana; Christie, Deborah; Bond, Lyndal; Scott, Stephen; Viner, Russell M

Trends in caesarean section rates between 2007 and 2013 in obstetric risk groups inspired by the Robson classification: results from population-based surveys in a low-resource setting. (2018) Hanson, C; Betrán, AP; Opondo, C; Mkumbo, E; Manzi, F; Mbaruku, G; Schellenberg, J

A systematic review and synthesis of theories of change of school-based interventions integrating health and academic education as a novel means of preventing violence and substance use among students. (2018) Tancred, Tara; Paparini, Sara; Melendez-Torres, GJ; Thomas, James; Fletcher, Adam; Campbell, Rona; Bonell, Chris

October 2018

Traumatic injury clinical trial evaluating tranexamic acid in children (TIC-TOC): study protocol for a pilot randomized controlled trial. (2018) Nishijima, Daniel K; VanBuren, John; Hewes, Hilary A; Myers, Sage R; Stanley, Rachel M; Adelson, P David; Barnhard, Sarah E; Bobinski, Matthew; Ghetti, Simona; Holmes, James F; Roberts, Ian; Schalick, Walton O; Tran, Nam K; Tzimenatos, Leah S; Michael Dean, J; Kuppermann, Nathan; TIC-TOC Collaborators of the Pediatric Emergency Care Applied Re

Outcome measures in clinical trials of treatments for acute severe haemorrhage. (2018) Brenner, Amy; Arribas, Monica; Cuzick, Jack; Jairath, Vipul; Stanworth, Simon; Ker, Katharine; Shakur-Still, Haleema; Roberts, Ian

September 2018

Tranexamic acid for significant traumatic brain injury (The CRASH-3 trial): Statistical analysis plan for an international, randomised, double-blind, placebo-controlled trial. (2018) Roberts, Ian; Belli, Antonio; Brenner, Amy; Chaudhri, Rizwana; Fawole, Bukola; Harris, Tim; Jooma, Rashid; Mahmood, Abda; Shokunbi, Temitayo; Shakur, Haleema

Integration of academic and health education for the prevention of physical aggression and violence in young people: systematic review, narrative synthesis and intervention components analysis. (2018) Melendez-Torres, GJ; Tancred, Tara; Fletcher, Adam; Campbell, Rona; Thomas, James; Bonell, Christopher

Defending evidence informed policy making from ideological attack. (2018) Bonell, Chris; Meiksin, Rebecca; Mays, Nicholas; Petticrew, Mark; McKee, Martin

Effects of Interventions Addressing School Environments or Educational Assets on Adolescent Sexual Health: Systematic Review and Meta-analysis. (2018) Peterson, Amy J; Donze, Melissa; Allen, Elizabeth; Bonell, Chris description

August 2018

Effect of tranexamic acid on coagulation and fibrinolysis in women with postpartum haemorrhage (WOMAN-ETAC): a single-centre, randomised, double-blind, placebo-controlled trial. (2018) Shakur-Still, Haleema; Roberts, Ian; Fawole, Bukola; Kuti, Modupe; Olayemi, Oladapo; Bello, Adenike; Huque, Sumaya; Ogunbode, Olayinka; Kotila, Taiwo; Aimakhu, Chris; Okunade, Olujide; Olutogun, Tolulase; Adetayo, Cecilia; Dallaku, Kastriot; Mansmann, Ulrich; Hunt, Beverley; Pepple, Tracey; Balogun, Eni

Effect of tranexamic acid on coagulation and fibrinolysis in women with postpartum haemorrhage (WOMAN-ETAC): a single-centre, randomised, double-blind, placebo-controlled trial. (2018) Shakur-Still, Haleema; Roberts, Ian; Fawole, Bukola; Kuti, Modupe; Olayemi, Oladapo O; Bello, Adenike; Huque, Sumaya; Ogunbode, Olayinka; Kotila, Taiwo; Aimakhu, Chris; Okunade, Olujide A; Olutogun, Tolulase; Adetayo, Cecilia O; Dallaku, Kastriot; Mansmann, Ulrich; Hunt, Beverley J; Pepple, Tracey; Balogun, Eni

Long-term mortality after blood pressure-lowering and lipid-lowering treatment in patients with hypertension in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) Legacy study: 16-year follow-up results of a randomised factorial trial. (2018) Gupta, Ajay; Mackay, Judith; Whitehouse, Andrew; Godec, Thomas; Collier, Tim; Pocock, Stuart; Poulter, Neil; Sever, Peter

July 2018

JACK trial protocol: a phase III multicentre cluster randomised controlled trial of a school-based relationship and sexuality education intervention focusing on young male perspectives. (2018) Lohan, Maria; Aventin, Áine; Clarke, Mike; Curran, Rhonda M; Maguire, Lisa; Hunter, Rachael; McDowell, Clíona; McDaid, Lisa; Young, Honor; White, James; Fletcher, Adam; French, Rebecca; Bonell, Christopher; Bailey, Julia V; O'Hare, Liam

Tranexamic acid for significant traumatic brain injury (The CRASH-3 trial): Statistical analysis plan for an international, randomised, double-blind, placebo-controlled trial. (2018) Roberts, Ian; Belli, Antonio; Brenner, Amy; Chaudhri, Rizwana; Fawole, Bukola; Harris, Tim; Jooma, Rashid; Mahmood, Abda; Shokunbi, Temitayo; Shakur, Haleema

Sustainable Undernutrition Reduction in Ethiopia (SURE) evaluation study: a protocol to evaluate impact, process and context of a large-scale integrated health and agriculture programme to improve complementary feeding in Ethiopia. (2018) Moss, Cami; Bekele, Tesfaye Hailu; Salasibew, Mihretab Melesse; Sturgess, Joanna; Ayana, Girmay; Kuche, Desalegn; Eshetu, Solomon; Abera, Andinet; Allen, Elizabeth; Dangour, Alan D

Can Teenage Men Be Targeted to Prevent Teenage Pregnancy? A Feasibility Cluster Randomised Controlled Intervention Trial in Schools. (2018) Lohan, Maria; Aventin, Áine; Clarke, Mike; Curran, Rhonda M; McDowell, Clíona; Agus, Ashley; McDaid, Lisa; Bonell, Chris; Young, Honor

School experiences and young women's pregnancy and parenthood decisions: A systematic review and synthesis of qualitative research. (2018) Peterson, Amy J; Bonell, Chris

Tranexamic acid for significant traumatic brain injury (The CRASH-3 trial): Statistical analysis plan for an international, randomised, double-blind, placebo-controlled trial. (2018) Roberts, Ian; Belli, Antonio; Brenner, Amy; Chaudhri, Rizwana; Fawole, Bukola; Harris, Tim; Jooma, Rashid; Mahmood, Abda; Shokunbi, Temitayo; Shakur, Haleema; CRASH-3 trial collaborators

"You have to keep your nerve on a DMC." Challenges for Data Monitoring Committees in neonatal intensive care trials: Qualitative accounts from the BRACELET Study. (2018) Snowdon, Claire; Brocklehurst, Peter; Tasker, Robert C; Ward Platt, Martin; Elbourne, Diana

Features of randomised trials designed by the NPEU Perinatal Trials Service during Adrian Grant's directorship. (2018) Elbourne, Diana

Associations between socio‐economic status (including school‐ and pupil‐level interactions) and student perceptions of school environment and health in English secondary schools. (2018) Shackleton, Nichola; Allen, Elizabeth; Bevilacqua, Leonardo; Viner, Russell; Bonell, Chris

The effect of high-flow nasal oxygen on hospital length of stay in cardiac surgical patients at high risk for respiratory complications: a randomised controlled trial. (2018) Zochios, V; Collier, T; Blaudszun, G; Butchart, A; Earwaker, M; Jones, N; Klein, AA

June 2018

Rationale and design of: A Randomized tRial of Expedited transfer to a cardiac arrest center for non-ST elevation out-of-hospital cardiac arrest: The ARREST randomized controlled trial. (2018) Patterson, Tiffany; Perkins, Alexander; Perkins, Gavin D; Clayton, Tim; Evans, Richard; Nguyen, Hanna; Wilson, Karen; Whitbread, Mark; Hughes, Johanna; Fothergill, Rachael T; Nevett, Joanne; Mosweu, Iris; McCrone, Paul; Dalby, Miles; Rakhit, Roby; MacCarthy, Philip; Perera, Divaka; Nolan, Jerry P; Redwood, Simon R

Women's work in UK clinical trials is undervalued. (2018) Roberts, Ian

Mobile phone-based interventions for improving adherence to medication prescribed for the primary prevention of cardiovascular disease in adults. (2018) Palmer, Melissa J; Barnard, Sharmani; Perel, Pablo; Free, Caroline

Risk factors associated with early smoking onset in two large birth cohorts. (2018) Staff, Jeremy; Maggs, Jennifer L; Ploubidis, George B; Bonell, Chris

The impact of early outcome events on the effect of tranexamic acid in post-partum haemorrhage: an exploratory subgroup analysis of the WOMAN trial. (2018) Brenner, Amy; Shakur-Still, Haleema; Chaudhri, Rizwana; Fawole, Bukola; Arulkumaran, Sabaratnam; Roberts, Ian; WOMAN Trial Collaborators

May 2018

Should hydroxyethyl starch be banned? - Authors' reply. (2018) Roberts, Ian; Shakur, Haleema; Bellomo, Rinaldo; Bion, Julian; Finfer, Simon; Hunt, Beverley; Myburgh, John; Perner, Anders; Reinhart, Konrad

Risk factors for peripartum hysterectomy among women with postpartum haemorrhage: analysis of data from the WOMAN trial. (2018) Huque, Sumaya; Roberts, Ian; Fawole, Bukola; Chaudhri, Rizwana; Arulkumaran, Sabaratnam; Shakur-Still, Haleema

Cochrane corner: text messaging to improve adherence to drugs for secondary prevention of cardiovascular disease. (2018) Adler, Alma J; Casas, Juan P; Martin, Nicole; Free, Caroline; Perel, Pablo

Haematological and fibrinolytic status of Nigerian women with post-partum haemorrhage. (2018) Roberts, Ian; Shakur, Haleema; Fawole, Bukola; Kuti, Modupe; Olayemi, Oladapo; Bello, Adenike; Ogunbode, Olayinka; Kotila, Taiwo; Aimakhu, Chris O; Olutogun, Tolulase; Hunt, Beverley J; Huque, Sumaya

Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial. (2018) Sprigg, Nikola; Flaherty, Katie; Appleton, Jason P; Al-Shahi Salman, Rustam; Bereczki, Daniel; Beridze, Maia; Christensen, Hanne; Ciccone, Alfonso; Collins, Ronan; Czlonkowska, Anna; Dineen, Robert A; Duley, Lelia; Egea-Guerrero, Juan Jose; England, Timothy J; Krishnan, Kailash; Laska, Ann Charlotte; Law, Zhe Kang; Ozturk, Serefnur; Pocock, Stuart J; Roberts, Ian; Robinson, Thompson G; Roffe, Christine; Seiffge, David; Scutt, Polly; Thanabalan, Jegan; Werring, David; Whynes, David; Bath, Philip M; TICH-2 Investigators

Study protocol for the optimisation, feasibility testing and pilot cluster randomised trial of Positive Choices: a school-based social marketing intervention to promote sexual health, prevent unintended teenage pregnancies and address health inequalities in England. (2018) Ponsford, Ruth; Allen, Elizabeth; Campbell, Rona; Elbourne, Diana; Hadley, Alison; Lohan, Maria; Melendez-Torres, GJ; Mercer, Catherine H; Morris, Steve; Young, Honor; Bonell, Chris

Development of an intervention delivered by mobile phone aimed at decreasing unintended pregnancy among young people in three lower middle income countries. (2018) McCarthy, Ona L; Wazwaz, Ola; Osorio Calderon, Veronica; Jado, Iman; Saibov, Salokhiddin; Stavridis, Amina; López Gallardo, Jhonny; Tokhirov, Ravshan; Adada, Samia; Huaynoca, Silvia; Makleff, Shelly; Vandewiele, Marieka; Standaert, Sarah; Free, Caroline

Implementation of the Good School Toolkit in Uganda: a quantitative process evaluation of a successful violence prevention program. (2018) Knight, Louise; Allen, Elizabeth; Mirembe, Angel; Nakuti, Janet; Namy, Sophie; Child, Jennifer C; Sturgess, Joanna; Kyegombe, Nambusi; Walakira, Eddy J; Elbourne, Diana; Naker, Dipak; Devries, Karen M

Percutaneous Revascularization for Ischemic Ventricular Dysfunction: Rationale and Design of the REVIVED-BCIS2 Trial: Percutaneous Coronary Intervention for Ischemic Cardiomyopathy. (2018) Perera, Divaka; Clayton, Tim; Petrie, Mark C; Greenwood, John P; O'Kane, Peter D; Evans, Richard; Sculpher, Mark; Mcdonagh, Theresa; Gershlick, Anthony; de Belder, Mark; Redwood, Simon; Carr-White, Gerald; Marber, Michael; REVIVED investigators

April 2018

Combined Protocol for Acute Malnutrition Study (ComPAS) in rural South Sudan and urban Kenya: study protocol for a randomized controlled trial. (2018) Bailey, Jeanette; Lelijveld, Natasha; Marron, Bethany; Onyoo, Pamela; Ho, Lara S; Manary, Mark; Briend, André; Opondo, Charles; Kerac, Marko

Effect of emotional content on online video sharing among health care professionals and researchers (DIFFUSION): results and lessons learnt from a randomised controlled trial. (2018) Kiriya, Junko; Edwards, Phil; Roberts, Ian

Amaze: a randomized controlled trial of adjunct surgery for atrial fibrillation. (2018) Nashef, Samer AM; Fynn, Simon; Abu-Omar, Yasir; Spyt, Tomasz J; Mills, Christine; Everett, Colin C; Fox-Rushby, Julia; Singh, Jeshika; Dalrymple-Hay, Malcolm; Sudarshan, Catherine; Codispoti, Massimiliano; Braidley, Peter; Wells, Francis C; Sharples, Linda D

Are randomised controlled trials positivist? Reviewing the social science and philosophy literature to assess positivist tendencies of trials of social interventions in public health and health services. (2018) Bonell, Chris; Moore, Graham; Warren, Emily; Moore, Laurence

The potential role for sociologists in designing RCTs and of RCTs in refining sociological theory: A commentary on Deaton and Cartwright. (2018) Bonell, Chris; Melendez-Torres, GJ; Quilley, Stephen

March 2018

Assessing the validity and reliability of self-report data on contraception use in the MObile Technology for Improved Family Planning (MOTIF) randomised controlled trial. (2018) Smith, Chris; Edwards, Phil; Free, Caroline

Upscaling Participatory Action and Videos for Agriculture and Nutrition (UPAVAN) trial comparing three variants of a nutrition-sensitive agricultural extension intervention to improve maternal and child nutritional outcomes in rural Odisha, India: study protocol for a cluster randomised controlled trial. (2018) Kadiyala, Suneetha; Prost, Audrey; Harris-Fry, Helen; O'Hearn, Meghan; Pradhan, Ronali; Pradhan, Shibananth; Mishra, Naba Kishore; Rath, Suchitra; Nair, Nirmala; Rath, Shibanand; Tripathy, Prasantha; Krishnan, Sneha; Koniz-Booher, Peggy; Danton, Heather; Elbourne, Diana; Sturgess, Joanna; Beaumont, Emma; Haghparast-Bidgoli, Hassan; Skordis-Worrall, Jolene; Mohanty, Satyanarayan; Upadhay, Avinash; Allen, Elizabeth

February 2018

Antifibrinolytic drugs for treating primary postpartum haemorrhage. (2018) Shakur, Haleema; Beaumont, Danielle; Pavord, Sue; Gayet-Ageron, Angele; Ker, Katharine; Mousa, Hatem A

Antifibrinolytic drugs for treating primary postpartum hemorrhage. (2018) Shakur, Haleema; Beaumont, Danielle; Pavord, Sue; Gayet-Ageron, Angele; Ker, Katharine; Mousa, Hatem A

Experiences of stigma and discrimination in social and healthcare settings among trans people living with HIV in the UK. (2018) Hibbert, M; Wolton, A; Crenna-Jennings, W; Benton, L; Kirwan, P; Lut, I; Okala, S; Ross, M; Furegato, M; Nambiar, K; Douglas, N; Roche, J; Jeffries, J; Reeves, I; Nelson, M; Weerawardhana, C; Jamal, Z; Hudson, A; Delpech, V

A randomized controlled trial of an intervention delivered by mobile phone app instant messaging to increase the acceptability of effective contraception among young people in Tajikistan. (2018) McCarthy, Ona; Ahamed, Irrfan; Kulaeva, Firuza; Tokhirov, Ravshan; Saibov, Salokhiddin; Vandewiele, Marieka; Standaert, Sarah; Leurent, Baptiste; Edwards, Phil; Palmer, Melissa; Free, Caroline

Does tranexamic acid lead to changes in MRI measures of brain tissue health in patients with spontaneous intracerebral haemorrhage? Protocol for a MRI substudy nested within the double-blind randomised controlled TICH-2 trial. (2018) Dineen, Rob A; Pszczolkowski, Stefan; Flaherty, Katie; Law, Zhe K; Morgan, Paul S; Roberts, Ian; Werring, David J; Al-Shahi Salman, Rustam; England, Tim; Bath, Philip M; Sprigg, Nikola

Hydroxyethyl starch solutions and patient harm. (2018) Roberts, Ian; Shakur, Haleema; Bellomo, Rinaldo; Bion, Julian; Finfer, Simon; Hunt, Beverley; Myburgh, John; Perner, Anders; Reinhart, Konrad

Does integrated academic and health education prevent substance use? Systematic review and meta-analyses. (2018) Melendez-Torres, GJ; Tancred, T; Fletcher, A; Thomas, J; Campbell, R; Bonell, C

Typology of drug use in United Kingdom men who have sex with men and associations with socio-sexual characteristics. (2018) Melendez-Torres, GJ; Bourne, Adam; Reid, David; Hickson, Ford; Bonell, Chris; Weatherburn, Peter

Comparing the characteristics of users of an online service for STI self-sampling with clinic service users: a cross-sectional analysis. (2018) Barnard, Sharmani; Free, Caroline; Bakolis, Ioannis; Turner, Katy ME; Looker, Katharine J; Baraitser, Paula

January 2018

The impact of digital health technologies on tuberculosis treatment: a systematic review. (2018) Ngwatu, Brian Kermu; Nsengiyumva, Ntwali Placide; Oxlade, Olivia; Mappin-Kasirer, Benjamin; Nguyen, Nhat Linh; Jaramillo, Ernesto; Falzon, Dennis; Schwartzman, Kevin; Collaborative group on the impact of digital technologies on TB

Post-partum haemorrhage and tranexamic acid: a global issue. (2018) Hibbs, Stephen P; Roberts, Ian; Shakur-Still, Haleema; Hunt, Beverley J picture_as_pdf

2018

Kangaroo mother care for clinically unstable neonates weighing ≤2000 g: Is it feasible at a hospital in Uganda? (2018) Morgan, Melissa C; Nambuya, Harriet; Waiswa, Peter; Tann, Cally; Elbourne, Diana; Seeley, Janet; Allen, Elizabeth; Lawn, Joy E

Finding Better Ways to Prevent Postpartum Hemorrhage. (2018) Shakur-Still, Haleema; Roberts, Ian

Amaze: a double-blind, multicentre randomised controlled trial to investigate the clinical effectiveness and cost-effectiveness of adding an ablation device-based maze procedure as an adjunct to routine cardiac surgery for patients with pre-existing atrial fibrillation. (2018) Sharples, Linda; Everett, Colin; Singh, Jeshika; Mills, Christine; Spyt, Tom; Abu-Omar, Yasir; Fynn, Simon; Thorpe, Benjamin; Stoneman, Victoria; Goddard, Hester; Fox-Rushby, Julia; Nashef, Samer