Adesanya, Elizabeth; Cook, Sarah; Crellin, Elizabeth; Langan, Sinead; Mansfield, Kathryn; Smeeth, Liam; Herrett, Emily; (2022) Alcohol use recording in adults with depression in English primary care: a cross-sectional study. BMJ open, 12 (1). e055975-. ISSN 2044-6055 DOI: https://doi.org/10.1136/bmjopen-2021-055975

Arvay, Melissa L; Shang, Nong; Qazi, Shamim A; Darmstadt, Gary L; Islam, Mohammad Shahidul; Roth, Daniel E; Liu, Anran; Connor, Nicholas E; Hossain, Belal; Sadeq-Ur Rahman, Qazi; +16 more... El Arifeen, Shams; Mullany, Luke C; Zaidi, Anita KM; Bhutta, Zulfiqar A; Soofi, Sajid B; Shafiq, Yasir; Baqui, Abdullah H; Mitra, Dipak K; Panigrahi, Pinaki; Panigrahi, Kalpana; Bose, Anuradha; Isaac, Rita; Westreich, Daniel; Meshnick, Steven R; Saha, Samir K; Schrag, Stephanie J; (2022) Infectious aetiologies of neonatal illness in south Asia classified using WHO definitions: a primary analysis of the ANISA study. The Lancet Global Health, 10 (9). e1289-e1297. ISSN 2214-109X DOI: https://doi.org/10.1016/S2214-109X(22)00244-3

Barbu, Miruna C; Amador, Carmen; Kwong, Alex SF; Shen, Xueyi; Adams, Mark J; Howard, David M; Walker, Rosie M; Morris, Stewart W; Min, Josine L; Genetics of DNA Methylation Consortium,; +9 more... Liu, Chunyu; van Dongen, Jenny; Ghanbari, Mohsen; Relton, Caroline; Porteous, David J; Campbell, Archie; Evans, Kathryn L; Whalley, Heather C; McIntosh, Andrew M; (2022) Complex trait methylation scores in the prediction of major depressive disorder. EBioMedicine, 79. 104000-. ISSN 2352-3964 DOI: https://doi.org/10.1016/j.ebiom.2022.104000

Battram, Thomas; Gaunt, Tom R; Relton, Caroline L; Timpson, Nicholas J; Hemani, Gibran; (2022) A comparison of the genes and genesets identified by GWAS and EWAS of fifteen complex traits. Nature communications, 13 (1). 7816-. ISSN 2041-1723 DOI: https://doi.org/10.1038/s41467-022-35037-3

Beynon, Rhona A; Ingle, Suzanne M; Langdon, Ryan; May, Margaret; Ness, Andy; Martin, Richard M; Suderman, Matthew; Ingarfield, Kate; Marioni, Riccardo E; McCartney, Daniel L; +5 more... Waterboer, Tim; Pawlita, Michael; Relton, Caroline; Smith, George Davey; Richmond, Rebecca C; (2022) Epigenetic biomarkers of ageing are predictive of mortality risk in a longitudinal clinical cohort of individuals diagnosed with oropharyngeal cancer. Clinical epigenetics, 14 (1). 1-. ISSN 1868-7075 DOI: https://doi.org/10.1186/s13148-021-01220-4

Bhaskaran, Krishnan; Rentsch, Christopher T; Hickman, George; Hulme, William J; Schultze, Anna; Curtis, Helen J; Wing, Kevin; Warren-Gash, Charlotte; Tomlinson, Laurie; Bates, Chris J; +22 more... Mathur, Rohini; MacKenna, Brian; Mahalingasivam, Viyaasan; Wong, Angel; Walker, Alex J; Morton, Caroline E; Grint, Daniel; Mehrkar, Amir; Eggo, Rosalind M; Inglesby, Peter; Douglas, Ian J; McDonald, Helen I; Cockburn, Jonathan; Williamson, Elizabeth J; Evans, David; Parry, John; Hester, Frank; Harper, Sam; Evans, Stephen Jw; Bacon, Sebastian; Smeeth, Liam; Goldacre, Ben; (2022) Overall and cause-specific hospitalisation and death after COVID-19 hospitalisation in England: A cohort study using linked primary care, secondary care, and death registration data in the OpenSAFELY platform. PLoS medicine, 19 (1). e1003871-. ISSN 1549-1277 DOI: https://doi.org/10.1371/journal.pmed.1003871

Bidulka, Patrick; Mathur, Rohini; Lugo-Palacios, David G; O'Neill, Stephen; Basu, Anirban; Silverwood, Richard J; Charlton, Paul; Briggs, Andrew; Smeeth, Liam; Adler, Amanda I; +3 more... Douglas, Ian J; Khunti, Kamlesh; Grieve, Richard; (2022) Ethnic and socioeconomic disparities in initiation of second-line antidiabetic treatment for people with type 2 diabetes in England: A cross-sectional study. Diabetes, obesity & metabolism, 25 (1). pp. 282-292. ISSN 1462-8902 DOI: https://doi.org/10.1111/dom.14874

Caramaschi, Doretta; Neumann, Alexander; Cardenas, Andres; Tindula, Gwen; Alemany, Silvia; Zillich, Lea; Pesce, Giancarlo; Lahti, Jari MT; Havdahl, Alexandra; Mulder, Rosa; +30 more... Felix, Janine F; Tiemeier, Henning; Sirignano, Lea; Frank, Josef; Witt, Stephanie H; Rietschel, Marcella; Deuschle, Michael; Huen, Karen; Eskenazi, Brenda; Send, Tabea Sarah; Ferrer, Muriel; Gilles, Maria; de Agostini, Maria; Baïz, Nour; Rifas-Shiman, Sheryl L; Kvist, Tuomas; Czamara, Darina; Tuominen, Samuli T; Relton, Caroline L; Rai, Dheeraj; London, Stephanie J; Räikkönen, Katri; Holland, Nina; Annesi-Maesano, Isabella; Streit, Fabian; Hivert, Marie-France; Oken, Emily; Sunyer, Jordi; Cecil, Charlotte AM; Sharp, Gemma; (2022) Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills. Molecular psychiatry, 27 (4). pp. 2126-2135. ISSN 1359-4184 DOI: https://doi.org/10.1038/s41380-022-01441-w

Charalampous, Periklis; Gorasso, Vanessa; Plass, Dietrich; Pires, Sara M; von der Lippe, Elena; Mereke, Alibek; Idavain, Jane; Kissimova-Skarbek, Katarzyna; Morgado, Joana Nazaré; Ngwa, Che Henry; +7 more... Noguer, Isabel; Padron-Monedero, Alicia; Santi-Cano, María José; Sarmiento, Rodrigo; Devleesschauwer, Brecht; Haagsma, Juanita A; COST Action CA18218 Participants; (2022) Burden of non-communicable disease studies in Europe: a systematic review of data sources and methodological choices. European Journal of Public Health, 32 (2). pp. 289-296. ISSN 1101-1262 DOI: https://doi.org/10.1093/eurpub/ckab218

Clarke, Sarah LN; Mageean, Katie S; Maccora, Ilaria; Harrison, Sean; Simonini, Gabriele; Sharp, Gemma C; Relton, Caroline L; Ramanan, Athimalaipet V; (2022) Moving from nature to nurture: a systematic review and meta-analysis of environmental factors associated with juvenile idiopathic arthritis. Rheumatology, 61 (2). pp. 514-530. ISSN 1462-0324 DOI: https://doi.org/10.1093/rheumatology/keab627

Clarke, Sarah LN; Richmond, Rebecca C; Zheng, Jie; Spiller, Wes; Ramanan, Athimalaipet V; Sharp, Gemma C; Relton, Caroline L; (2022) Examining Health Outcomes in Juvenile Idiopathic Arthritis: A Genetic Epidemiology Study. ACR open rheumatology, 4 (4). pp. 363-370. ISSN 2578-5745 DOI: https://doi.org/10.1002/acr2.11404

Connor, Nicholas E; Islam, Mohammad Shahidul; Mullany, Luke C; Shang, Nong; Bhutta, Zulfiqar A; Zaidi, Anita KM; Soofi, Sajid; Nisar, Imran; Panigrahi, Pinaki; Panigrahi, Kalpana; +22 more... Satpathy, Radhanath; Bose, Anuradha; Isaac, Rita; Baqui, Abdullah H; Mitra, Dipak K; Sadeq-Ur Rahman, Qazi; Hossain, Tanvir; Schrag, Stephanie J; Winchell, Jonas M; Arvay, Melissa L; Diaz, Maureen H; Waller, Jessica L; Weber, Martin W; Hamer, Davidson H; Hibberd, Patricia; Nawshad Uddin Ahmed, ASM; Islam, Maksuda; Hossain, Mohammad Belal; Qazi, Shamim A; El Arifeen, Shams; Darmstadt, Gary L; Saha, Samir K; (2022) Risk factors for community-acquired bacterial infection among young infants in South Asia: a longitudinal cohort study with nested case-control analysis. BMJ global health, 7 (11). e009706-e009706. ISSN 2059-7908 DOI: https://doi.org/10.1136/bmjgh-2022-009706

Corbin, Laura J; White, Stephen J; Taylor, Amy E; Williams, Christopher M; Taylor, Kurt; van den Bosch, Marion T; Teasdale, Jack E; Jones, Matthew; Bond, Mark; Harper, Matthew T; +14 more... Falk, Louise; Groom, Alix; Hazell, Georgina GJ; Paternoster, Lavinia; Munafò, Marcus R; Nordestgaard, Børge G; Tybjærg-Hansen, Anne; Bojesen, Stig E; Relton, Caroline; Min, Josine L; Davey Smith, George; Mumford, Andrew D; Poole, Alastair W; Timpson, Nicholas J; (2022) Epigenetic Regulation of F2RL3 Associates With Myocardial Infarction and Platelet Function. Circulation research, 130 (3). pp. 384-400. ISSN 0009-7330 DOI: https://doi.org/10.1161/CIRCRESAHA.121.318836

Curtis, Helen J; Inglesby, Peter; MacKenna, Brian; Croker, Richard; Hulme, William J; Rentsch, Christopher T; Bhaskaran, Krishnan; Mathur, Rohini; Morton, Caroline E; Bacon, Sebastian Cj; +27 more... Smith, Rebecca M; Evans, David; Mehrkar, Amir; Tomlinson, Laurie; Walker, Alex J; Bates, Christopher; Hickman, George; Ward, Tom; Morley, Jessica; Cockburn, Jonathan; Davy, Simon; Williamson, Elizabeth J; Eggo, Rosalind M; Parry, John; Hester, Frank; Harper, Sam; O'Hanlon, Shaun; Eavis, Alex; Jarvis, Richard; Avramov, Dima; Griffiths, Paul; Fowles, Aaron; Parkes, Nasreen; Evans, Stephen Jw; Douglas, Ian J; Smeeth, Liam; Goldacre, Ben; (2022) Recording of 'COVID-19 vaccine declined': a cohort study on 57.9 million National Health Service patients' records in situ using OpenSAFELY, England, 8 December 2020 to 25 May 2021. Eurosurveillance, 27 (33). ISSN 1560-7917 DOI: https://doi.org/10.2807/1560-7917.ES.2022.27.33.2100885

Davidson, Jennifer A; Banerjee, Amitava; Douglas, Ian; Leyrat, Clémence; Pebody, Richard; McDonald, Helen I; Herrett, Emily; Forbes, Harriet; Smeeth, Liam; Warren-Gash, Charlotte; (2022) Primary prevention of acute cardiovascular events by influenza vaccination: an observational study. European heart journal, 44 (7). pp. 610-620. ISSN 0195-668X DOI: https://doi.org/10.1093/eurheartj/ehac737

Elliott, Hannah R; Burrows, Kimberley; Min, Josine L; Tillin, Therese; Mason, Dan; Wright, John; Santorelli, Gillian; Davey Smith, George; Lawlor, Deborah A; Hughes, Alun D; +2 more... Chaturvedi, Nishi; Relton, Caroline L; (2022) Characterisation of ethnic differences in DNA methylation between UK-resident South Asians and Europeans. Clinical epigenetics, 14 (1). 130-. ISSN 1868-7075 DOI: https://doi.org/10.1186/s13148-022-01351-2

Fabian, June; Kalyesubula, Robert; Mkandawire, Joseph; Hansen, Christian Holm; Nitsch, Dorothea; Musenge, Eustasius; Nakanga, Wisdom P; Prynn, Josephine E; Dreyer, Gavin; Snyman, Tracy; +10 more... Ssebunnya, Billy; Ramsay, Michele; Smeeth, Liam; Tollman, Stephen; Naicker, Saraladevi; Crampin, Amelia; Newton, Robert; George, Jaya A; Tomlinson, Laurie; African Research on Kidney Disease Consortium; (2022) Measurement of kidney function in Malawi, South Africa, and Uganda: a multicentre cohort study. The Lancet Global health, 10 (8). e1159-e1169. ISSN 2214-109X DOI: https://doi.org/10.1016/S2214-109X(22)00239-X

Herrett, Emily; Strongman, Helen; Gadd, Sarah; Tomlinson, Laurie; Nitsch, Dorothea; Bhaskaran, Krishnan; Williamson, Elizabeth; van Staa, Tjeerd; Sofat, Reecha; Timmis, Adam; +3 more... Wells, Susan; Smeeth, Liam; Jackson, Rod; (2022) The importance of blood pressure thresholds versus predicted cardiovascular risk on subsequent rates of cardiovascular disease: a cohort study in English primary care. The Lancet Global Health, 3 (1). e22-e30. ISSN 2214-109X DOI: https://doi.org/10.1016/S2666-7568(21)00281-6

Hulme, William J; Williamson, Elizabeth J; Green, Amelia CA; Bhaskaran, Krishnan; McDonald, Helen I; Rentsch, Christopher T; Schultze, Anna; Tazare, John; Curtis, Helen J; Walker, Alex J; +32 more... Tomlinson, Laurie A; Palmer, Tom; Horne, Elsie MF; MacKenna, Brian; Morton, Caroline E; Mehrkar, Amir; Morley, Jessica; Fisher, Louis; Bacon, Sebastian CJ; Evans, David; Inglesby, Peter; Hickman, George; Davy, Simon; Ward, Tom; Croker, Richard; Eggo, Rosalind M; Wong, Angel YS; Mathur, Rohini; Wing, Kevin; Forbes, Harriet; Grint, Daniel J; Douglas, Ian J; Evans, Stephen JW; Smeeth, Liam; Bates, Chris; Cockburn, Jonathan; Parry, John; Hester, Frank; Harper, Sam; Sterne, Jonathan AC; Hernán, Miguel A; Goldacre, Ben; (2022) Comparative effectiveness of ChAdOx1 versus BNT162b2 covid-19 vaccines in health and social care workers in England: cohort study using OpenSAFELY. BMJ, 378. e068946-. DOI: https://doi.org/10.1136/bmj-2021-068946

Kalyesubula, Robert; Sekitoleko, Isaac; Tomlin, Keith; Hansen, Christian Holm; Ssebunya, Billy; Makanga, Ronald; Mbonye, Moses Kwizera; Seeley, Janet; Smeeth, Liam; Newton, Robert; +1 more... Tomlinson, Laurie A; (2022) Association of impaired kidney function with mortality in rural Uganda: results of a general population cohort study. BMJ Open, 12 (4). e051267-. ISSN 2044-6055 DOI: https://doi.org/10.1136/bmjopen-2021-051267

Kibirige, Davis; Sekitoleko, Isaac; Balungi, Priscilla; Kyosiimire-Lugemwa, Jacqueline; Lumu, William; Jones, Angus G; Hattersley, Andrew T; Smeeth, Liam; Nyirenda, Moffat J; (2022) Islet autoantibody positivity in an adult population with recently diagnosed diabetes in Uganda. PloS One, 17 (5). e0268783-. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0268783

Kibirige, Davis; Sekitoleko, Isaac; Lumu, William; Jones, Angus G; Hattersley, Andrew T; Smeeth, Liam; Nyirenda, Moffat J; (2022) Understanding the pathogenesis of lean non-autoimmune diabetes in an African population with newly diagnosed diabetes. Diabetologia, 65 (4). pp. 675-683. ISSN 0012-186X DOI: https://doi.org/10.1007/s00125-021-05644-8

Kreitmaier, Peter; Suderman, Matthew; Southam, Lorraine; Coutinho de Almeida, Rodrigo; Hatzikotoulas, Konstantinos; Meulenbelt, Ingrid; Steinberg, Julia; Relton, Caroline L; Wilkinson, J Mark; Zeggini, Eleftheria; (2022) An epigenome-wide view of osteoarthritis in primary tissues. American journal of human genetics, 109 (7). pp. 1255-1271. ISSN 0002-9297 DOI: https://doi.org/10.1016/j.ajhg.2022.05.010

Lazo-Porras, Maria; Bernabe-Ortiz, Antonio; Gilman, Robert H; Checkley, William; Smeeth, Liam; Miranda, J Jaime; (2022) Population-based stroke incidence estimates in Peru: Exploratory results from the CRONICAS cohort study. Lancet Regional Health. Americas, 5. p. 100083. ISSN 2667-193X DOI: https://doi.org/10.1016/j.lana.2021.100083

Li, Liang; Zhang, Hongmei; Holloway, John W; Ewart, Susan; Relton, Caroline L; Arshad, S Hasan; Karmaus, Wilfried; (2022) Does DNA methylation mediate the association of age at puberty with forced vital capacity or forced expiratory volume in 1 s? ERJ open research, 8 (1). 00476-2021. ISSN 2312-0541 DOI: https://doi.org/10.1183/23120541.00476-2021

Lin, Liang-Yu; Mathur, Rohini; Mulick, Amy; Smeeth, Liam; Langan, Sinéad M; Warren-Gash, Charlotte; (2022) Association between vitamin D and incident herpes zoster: a UK Biobank study. British Journal of General Practice, 72 (724). e842-e848. ISSN 0960-1643 DOI: https://doi.org/10.3399/BJGP.2021.0623

Lin, Liang-Yu; Mulick, Amy; Mathur, Rohini; Smeeth, Liam; Warren-Gash, Charlotte; Langan, Sinéad M; (2022) The association between vitamin D status and COVID-19 in England: A cohort study using UK Biobank. PloS One, 17 (6). e0269064-. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0269064

Lozano, Manuel; Yousefi, Paul; Broberg, Karin; Soler-Blasco, Raquel; Miyashita, Chihiro; Pesce, Giancarlo; Kim, Woo Jin; Rahman, Mohammad; Bakulski, Kelly M; Haug, Line S; +18 more... Ikeda-Araki, Atsuko; Huel, Guy; Park, Jaehyun; Relton, Caroline; Vrijheid, Martine; Rifas-Shiman, Sheryl; Oken, Emily; Dou, John F; Kishi, Reiko; Gutzkow, Kristine B; Annesi-Maesano, Isabella; Won, Sungho; Hivert, Marie-France; Fallin, M Daniele; Vafeiadi, Marina; Ballester, Ferran; Bustamante, Mariona; Llop, Sabrina; (2022) DNA methylation changes associated with prenatal mercury exposure: A meta-analysis of prospective cohort studies from PACE consortium. Environmental research, 204 (Pt B). 112093-. ISSN 0013-9351 DOI: https://doi.org/10.1016/j.envres.2021.112093

MacKenna, Brian; Kennedy, Nicholas A; Mehrkar, Amir; Rowan, Anna; Galloway, James; Matthewman, Julian; Mansfield, Kathryn E; Bechman, Katie; Yates, Mark; Brown, Jeremy; +38 more... Schultze, Anna; Norton, Sam; Walker, Alex J; Morton, Caroline E; Harrison, David; Bhaskaran, Krishnan; Rentsch, Christopher T; Williamson, Elizabeth; Croker, Richard; Bacon, Seb; Hickman, George; Ward, Tom; Davy, Simon; Green, Amelia; Fisher, Louis; Hulme, William; Bates, Chris; Curtis, Helen J; Tazare, John; Eggo, Rosalind M; Evans, David; Inglesby, Peter; Cockburn, Jonathan; McDonald, Helen I; Tomlinson, Laurie A; Mathur, Rohini; Wong, Angel YS; Forbes, Harriet; Parry, John; Hester, Frank; Harper, Sam; Douglas, Ian J; Smeeth, Liam; Lees, Charlie W; Evans, Stephen JW; Goldacre, Ben; Smith, Catherine H; Langan, Sinéad M; (2022) Risk of severe COVID-19 outcomes associated with immune-mediated inflammatory diseases and immune-modifying therapies: a nationwide cohort study in the OpenSAFELY platform. The Lancet Rheumatology, 4 (7). e490-e506. ISSN 2665-9913 DOI: https://doi.org/10.1016/S2665-9913(22)00098-4

Manno, Daniela; Bangura, Agnes; Baiden, Frank; Kamara, Abu Bakarr; Ayieko, Philip; Kallon, Joseph; Foster, Julie; Conteh, Musa; Connor, Nicholas Edward; Koroma, Bockarie; +20 more... Njie, Yusupha; Borboh, Paul; Keshinro, Babajide; Lawal, Bolarinde Joseph; Kroma, Mattu Tehtor; Otieno, Godfrey Tuda; Deen, Abdul Tejan; Choi, Edward Man-Lik; Balami, Ahmed Dahiru; Gaddah, Auguste; McLean, Chelsea; Luhn, Kerstin; Adetola, Hammed Hassan; Deen, Gibrilla Fadlu; Samai, Mohamed; Lowe, Brett; Robinson, Cynthia; Leigh, Bailah; Greenwood, Brian; Watson-Jones, Deborah; (2022) Safety and immunogenicity of an Ad26.ZEBOV booster dose in children previously vaccinated with the two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen: an open-label, non-randomised, phase 2 trial. The Lancet. Infectious diseases, 23 (3). pp. 352-360. ISSN 1473-3099 DOI: https://doi.org/10.1016/S1473-3099(22)00594-1

Mensink-Bout, Sara M; van Meel, Evelien R; de Jongste, Johan C; Annesi-Maesano, Isabella; Aubert, Adrien M; Bernard, Jonathan Y; Chen, Ling-Wei; Cooper, Cyrus; Crozier, Sarah R; Hanke, Wojciech; +14 more... Harvey, Nicholas C; Hébert, James R; Heude, Barbara; Jerzynska, Joanna; Kelleher, Cecily C; Mehegan, John; McAuliffe, Fionnuala M; Phillips, Catherine M; Polanska, Kinga; Relton, Caroline L; Shivappa, Nitin; Suderman, Matthew; Jaddoe, Vincent WV; Duijts, Liesbeth; (2022) Maternal diet in pregnancy and child's respiratory outcomes: an individual participant data meta-analysis of 18 000 children. The European respiratory journal, 59 (4). p. 2101315. ISSN 0903-1936 DOI: https://doi.org/10.1183/13993003.01315-2021

Morales Berstein, Fernanda; McCartney, Daniel L; Lu, Ake T; Tsilidis, Konstantinos K; Bouras, Emmanouil; Haycock, Philip; Burrows, Kimberley; Phipps, Amanda I; Buchanan, Daniel D; Cheng, Iona; +8 more... PRACTICAL consortium; Martin, Richard M; Davey Smith, George; Relton, Caroline L; Horvath, Steve; Marioni, Riccardo E; Richardson, Tom G; Richmond, Rebecca C; (2022) Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study. eLife, 11. e75374-. ISSN 2050-084X DOI: https://doi.org/10.7554/eLife.75374

Muzambi, Rutendo; Bhaskaran, Krishnan; Rentsch, Christopher T; Smeeth, Liam; Brayne, Carol; Garfield, Victoria; Williams, Dylan M; Chaturvedi, Nish; Warren-Gash, Charlotte; (2022) Are infections associated with cognitive decline and neuroimaging outcomes? A historical cohort study using data from the UK Biobank study linked to electronic health records. Translational psychiatry, 12 (1). 385-. ISSN 2158-3188 DOI: https://doi.org/10.1038/s41398-022-02145-z

Odintsova, Veronika V; Suderman, Matthew; Hagenbeek, Fiona A; Caramaschi, Doretta; Hottenga, Jouke-Jan; Pool, René; BIOS Consortium; Dolan, Conor V; Ligthart, Lannie; van Beijsterveldt, Catharina EM; +10 more... Willemsen, Gonneke; de Geus, Eco JC; Beck, Jeffrey J; Ehli, Erik A; Cuellar-Partida, Gabriel; Evans, David M; Medland, Sarah E; Relton, Caroline L; Boomsma, Dorret I; van Dongen, Jenny; (2022) DNA methylation in peripheral tissues and left-handedness. Scientific reports, 12 (1). 5606-. ISSN 2045-2322 DOI: https://doi.org/10.1038/s41598-022-08998-0

OpenSAFELY Collaborative; Green, Amelia; Curtis, Helen; Hulme, William; Williamson, Elizabeth; McDonald, Helen; Bhaskaran, Krishnan; Rentsch, Christopher; Schultze, Anna; MacKenna, Brian; +32 more... Mahalingasivam, Viyaasan; Tomlinson, Laurie; Walker, Alex; Fisher, Louis; Massey, Jon; Andrews, Colm; Hopcroft, Lisa; Morton, Caroline; Croker, Richard; Morley, Jessica; Mehrkar, Amir; Bacon, Seb; Evans, David; Inglesby, Peter; Hickman, George; Ward, Tom; Davy, Simon; Mathur, Rohini; Tazare, John; Eggo, Rosalind; Wing, Kevin; Wong, Angel; Forbes, Harriet; Bates, Chris; Cockburn, Jonathan; Parry, John; Hester, Frank; Harper, Sam; Douglas, Ian; Evans, Stephen; Smeeth, Liam; Goldacre, Ben; (2022) Describing the population experiencing COVID-19 vaccine breakthrough following second vaccination in England: a cohort study from OpenSAFELY. BMC medicine, 20 (1). 243-. ISSN 1741-7015 DOI: https://doi.org/10.1186/s12916-022-02422-0

OpenSAFELY Collaborative; Tazare, John; Walker, Alex J; Tomlinson, Laurie A; Hickman, George; Rentsch, Christopher T; Williamson, Elizabeth J; Bhaskaran, Krishnan; Evans, David; Wing, Kevin; +31 more... Mathur, Rohini; Wong, Angel Ys; Schultze, Anna; Bacon, Seb; Bates, Chris; Morton, Caroline E; Curtis, Helen J; Nightingale, Emily; McDonald, Helen I; Mehrkar, Amir; Inglesby, Peter; Davy, Simon; MacKenna, Brian; Cockburn, Jonathan; Hulme, William J; Warren-Gash, Charlotte; Bhate, Ketaki; Nitsch, Dorothea; Powell, Emma; Mulick, Amy; Forbes, Harriet; Minassian, Caroline; Croker, Richard; Parry, John; Hester, Frank; Harper, Sam; Eggo, Rosalind M; Evans, Stephen Jw; Smeeth, Liam; Douglas, Ian J; Goldacre, Ben; (2022) Rates of serious clinical outcomes in survivors of hospitalisation with COVID-19 in England: a descriptive cohort study within the OpenSAFELY platform. Wellcome open research, 7. 142-. ISSN 2398-502X DOI: https://doi.org/10.12688/wellcomeopenres.17735.1

OpenSAFELY Collaborative; Williamson, Elizabeth J; Tazare, John; Bhaskaran, Krishnan; McDonald, Helen I; Walker, Alex J; Tomlinson, Laurie; Wing, Kevin; Bacon, Sebastian; Bates, Chris; +35 more... Curtis, Helen J; Forbes, Harriet J; Minassian, Caroline; Morton, Caroline E; Nightingale, Emily; Mehrkar, Amir; Evans, David; Nicholson, Brian D; Leon, David A; Inglesby, Peter; MacKenna, Brian; Davies, Nicholas G; DeVito, Nicholas J; Drysdale, Henry; Cockburn, Jonathan; Hulme, William J; Morley, Jessica; Douglas, Ian; Rentsch, Christopher T; Mathur, Rohini; Wong, Angel; Schultze, Anna; Croker, Richard; Parry, John; Hester, Frank; Harper, Sam; Grieve, Richard; Harrison, David A; Steyerberg, Ewout W; Eggo, Rosalind M; Diaz-Ordaz, Karla; Keogh, Ruth; Evans, Stephen JW; Smeeth, Liam; Goldacre, Ben; (2022) Comparison of methods for predicting COVID-19-related death in the general population using the OpenSAFELY platform. Diagnostic and prognostic research, 6 (1). 6-. ISSN 2397-7523 DOI: https://doi.org/10.1186/s41512-022-00120-2

Paixao, Enny S; Cardim, Luciana L; Costa, Maria CN; Brickley, Elizabeth B; de Carvalho-Sauer, Rita CO; Carmo, Eduardo H; Andrade, Roberto FS; Rodrigues, Moreno S; Veiga, Rafael V; Costa, Larissa C; +6 more... Moore, Cynthia A; França, Giovanny VA; Smeeth, Liam; Rodrigues, Laura C; Barreto, Mauricio L; Teixeira, Maria G; (2022) Mortality from Congenital Zika Syndrome - Nationwide Cohort Study in Brazil. The New England journal of medicine, 386 (8). pp. 757-767. ISSN 0028-4793 DOI: https://doi.org/10.1056/NEJMoa2101195

Paixao, Enny S; Rodrigues, Laura C; Costa, Maria da Conceição N; de Carvalho-Sauer, Rita de Cassia Oliveira; Oliveira, Wanderson K; Cardim, Luciana L; Schuler-Faccini, Lavinia; Andrade, Roberto FS; Rodrigues, Moreno S; Brickley, Elizabeth B; +6 more... Veiga, Rafael V; Costa, Larissa C; Carmo, Eduardo H; Smeeth, Liam; Barreto, Mauricio L; Teixeira, Maria Gloria; (2022) Population-based surveillance for congenital zika virus syndrome: a latent class analysis of recorded cases from 2015-2018. BMC Pregnancy and Childbirth, 22 (1). 530-. ISSN 1471-2393 DOI: https://doi.org/10.1186/s12884-022-04860-3

Paixão, Enny S; Fernandes, Qeren Hapuk R Ferreira; Cardim, Luciana L; Pescarini, Julia M; Costa, Maria Conceicao N; Falcão, Ila R; Brickley, Elizabeth B; Santos, Andreia Costa; Portela Souza, André; Carvalho-Sauer, Rita de Cassia Oliveira; +4 more... Smeeth, Liam; Rodrigues, Laura C; Barreto, Mauricio L; Teixeira, Maria Gloria; (2022) Socioeconomic risk markers of congenital Zika syndrome: a nationwide, registry-based study in Brazil. BMJ Global Health, 7 (9). e009600-e009600. ISSN 2059-7908 DOI: https://doi.org/10.1136/bmjgh-2022-009600

Pescarini, Julia M; Campbell, Desmond; Amorim, Leila D; Falcão, Ila R; Ferreira, Andrêa JF; Allik, Mirjam; Shaw, Richard J; Malta, Deborah C; Ali, M Sanni; Smeeth, Liam; +5 more... Barreto, Mauricio L; Leyland, Alastair; Craig, Peter; Aquino, Estela ML; Katikireddi, Srinivasa Vittal; (2022) Impact of Brazil's Bolsa Família Programme on cardiovascular and all-cause mortality: a natural experiment study using the 100 Million Brazilian Cohort. International journal of epidemiology, 51 (6). pp. 1847-1861. ISSN 0300-5771 DOI: https://doi.org/10.1093/ije/dyac188

Pescarini, Julia M; Rodrigues, Moreno; Paixão, Enny S; Cardim, Luciana; Brito, Carlos AA de; Costa, Maria da Conceição N; Santos, Andreia C; Smeeth, Liam; Teixeira, Maria da Glória; Souza, André PF de; +2 more... Barreto, Mauricio L; Brickley, Elizabeth B; (2022) Dengue, Zika, and Chikungunya viral circulation and hospitalization rates in Brazil from 2014 to 2019: An ecological study. PLoS Neglected Tropical Diseases, 16 (7). e0010602-. ISSN 1935-2735 DOI: https://doi.org/10.1371/journal.pntd.0010602

Rathod, Aniruddha; Zhang, Hongmei; Arshad, Syed Hasan; Ewart, Susan; Relton, Caroline L; Karmaus, Wilfried; Holloway, John W; (2022) DNA Methylation and Asthma Acquisition during Adolescence and Post-Adolescence, an Epigenome-Wide Longitudinal Study. Journal of personalized medicine, 12 (2). p. 202. ISSN 2075-4426 DOI: https://doi.org/10.3390/jpm12020202

Richardson, Tom G; O'Nunain, Katie; Relton, Caroline L; Davey Smith, George; (2022) Harnessing Whole Genome Polygenic Risk Scores to Stratify Individuals Based on Cardiometabolic Risk Factors and Biomarkers at Age 10 in the Lifecourse-Brief Report. Arteriosclerosis, thrombosis, and vascular biology, 42 (3). pp. 362-365. ISSN 1079-5642 DOI: https://doi.org/10.1161/ATVBAHA.121.316650

Rijlaarsdam, Jolien; Cecil, Charlotte AM; Relton, Caroline L; Barker, Edward D; (2022) Epigenetic profiling of social communication trajectories and co-occurring mental health problems: a prospective, methylome-wide association study. Development and psychopathology, 34 (3). pp. 854-863. ISSN 0954-5794 DOI: https://doi.org/10.1017/S0954579420001662

Schultze, Anna; Nightingale, Emily; Evans, David; Hulme, William; Rosello, Alicia; Bates, Chris; Cockburn, Jonathan; MacKenna, Brian; Curtis, Helen J; Morton, Caroline E; +32 more... Croker, Richard; Bacon, Seb; McDonald, Helen I; Rentsch, Christopher T; Bhaskaran, Krishnan; Mathur, Rohini; Tomlinson, Laurie A; Williamson, Elizabeth J; Forbes, Harriet; Tazare, John; Grint, Daniel; Walker, Alex J; Inglesby, Peter; DeVito, Nicholas J; Mehrkar, Amir; Hickman, George; Davy, Simon; Ward, Tom; Fisher, Louis; Green, Amelia Ca; Wing, Kevin; Wong, Angel Ys; McManus, Robert; Parry, John; Hester, Frank; Harper, Sam; Evans, Stephen Jw; Douglas, Ian J; Smeeth, Liam; Eggo, Rosalind M; Goldacre, Ben; Leon, David A; (2022) Mortality among Care Home Residents in England during the first and second waves of the COVID-19 pandemic: an observational study of 4.3 million adults over the age of 65. The Lancet regional health. Europe, 14. 100295-. ISSN 2666-7762 DOI: https://doi.org/10.1016/j.lanepe.2021.100295

Shen, Xueyi; Caramaschi, Doretta; Adams, Mark J; Walker, Rosie M; Min, Josine L; Kwong, Alex; Hemani, Gibran; Genetics of DNA Methylation Consortium; Barbu, Miruna C; Whalley, Heather C; +8 more... Harris, Sarah E; Deary, Ian J; Morris, Stewart W; Cox, Simon R; Relton, Caroline L; Marioni, Riccardo E; Evans, Kathryn L; McIntosh, Andrew M; Genetics of DNA Methylation Consortium; (2022) DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses. Genome medicine, 14 (1). 36-. ISSN 1756-994X DOI: https://doi.org/10.1186/s13073-022-01039-5

Solomon, Olivia; Huen, Karen; Yousefi, Paul; Küpers, Leanne K; González, Juan R; Suderman, Matthew; Reese, Sarah E; Page, Christian M; Gruzieva, Olena; Rzehak, Peter; +75 more... Gao, Lu; Bakulski, Kelly M; Novoloaca, Alexei; Allard, Catherine; Pappa, Irene; Llambrich, Maria; Vives, Marta; Jima, Dereje D; Kvist, Tuomas; Baccarelli, Andrea; White, Cory; Rezwan, Faisal I; Sharp, Gemma C; Tindula, Gwen; Bergström, Anna; Grote, Veit; Dou, John F; Isaevska, Elena; Magnus, Maria C; Corpeleijn, Eva; Perron, Patrice; Jaddoe, Vincent WV; Nohr, Ellen A; Maitre, Lea; Foraster, Maria; Hoyo, Cathrine; Håberg, Siri E; Lahti, Jari; DeMeo, Dawn L; Zhang, Hongmei; Karmaus, Wilfried; Kull, Inger; Koletzko, Berthold; Feinberg, Jason I; Gagliardi, Luigi; Bouchard, Luigi; Ramlau-Hansen, Cecilia Høst; Tiemeier, Henning; Santorelli, Gillian; Maguire, Rachel L; Czamara, Darina; Litonjua, Augusto A; Langhendries, Jean-Paul; Plusquin, Michelle; Lepeule, Johanna; Binder, Elisabeth B; Verduci, Elvira; Dwyer, Terence; Carracedo, Ángel; Ferre, Natalia; Eskenazi, Brenda; Kogevinas, Manolis; Nawrot, Tim S; Munthe-Kaas, Monica C; Herceg, Zdenko; Relton, Caroline; Melén, Erik; Gruszfeld, Dariusz; Breton, Carrie; Fallin, MD; Ghantous, Akram; Nystad, Wenche; Heude, Barbara; Snieder, Harold; Hivert, Marie-France; Felix, Janine F; Sørensen, Thorkild IA; Bustamante, Mariona; Murphy, Susan K; Raikkönen, Katri; Oken, Emily; Holloway, John W; Arshad, Syed Hasan; London, Stephanie J; Holland, Nina; (2022) Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation. Mutation research. Reviews in mutation research, 789. 108415-. ISSN 1383-5742 DOI: https://doi.org/10.1016/j.mrrev.2022.108415

Strongman, Helen; Gadd, Sarah; Matthews, Anthony A; Mansfield, Kathryn E; Stanway, Susannah; Lyon, Alexander R; Dos-Santos-Silva, Isabel; Smeeth, Liam; Bhaskaran, Krishnan; (2022) Does Cardiovascular Mortality Overtake Cancer Mortality During Cancer Survivorship?: An English Retrospective Cohort Study. JACC: CardioOncology, 4 (1). pp. 113-123. ISSN 2666-0873 DOI: https://doi.org/10.1016/j.jaccao.2022.01.102

Strongman, Helen; Herrett, Emily; Jackson, Rod; Sweeting, Michael; Lyon, Alexander R; Stanway, Susannah; Lawson, Claire; Kadam, Umesh; Smeeth, Liam; Bhaskaran, Krishnan; (2022) Cancer history as a predictor in cardiovascular risk scores: a primary care cohort study. The British journal of general practice, 73 (726). e34-e42. ISSN 0960-1643 DOI: https://doi.org/10.3399/BJGP.2022.0088

Wade, Kaitlin H; Yarmolinsky, James; Giovannucci, Edward; Lewis, Sarah J; Millwood, Iona Y; Munafò, Marcus R; Meddens, Fleur; Burrows, Kimberley; Bell, Joshua A; Davies, Neil M; +29 more... Mariosa, Daniela; Kanerva, Noora; Vincent, Emma E; Smith-Byrne, Karl; Guida, Florence; Gunter, Marc J; Sanderson, Eleanor; Dudbridge, Frank; Burgess, Stephen; Cornelis, Marilyn C; Richardson, Tom G; Borges, Maria Carolina; Bowden, Jack; Hemani, Gibran; Cho, Yoonsu; Spiller, Wes; Richmond, Rebecca C; Carter, Alice R; Langdon, Ryan; Lawlor, Deborah A; Walters, Robin G; Vimaleswaran, Karani Santhanakrishnan; Anderson, Annie; Sandu, Meda R; Tilling, Kate; Davey Smith, George; Martin, Richard M; Relton, Caroline L; with the M. R. in Nutrition, Cancer working group; (2022) Applying Mendelian randomization to appraise causality in relationships between nutrition and cancer. Cancer causes & control : CCC, 33 (5). pp. 631-652. ISSN 0957-5243 DOI: https://doi.org/10.1007/s10552-022-01562-1

Walker, Jemma L; Schultze, Anna; Tazare, John; Tamborska, Arina; Singh, Bhagteshwar; Donegan, Katherine; Stowe, Julia; Morton, Caroline E; Hulme, William J; Curtis, Helen J; +27 more... Williamson, Elizabeth J; Mehrkar, Amir; Eggo, Rosalind M; Rentsch, Christopher T; Mathur, Rohini; Bacon, Sebastian; Walker, Alex J; Davy, Simon; Evans, David; Inglesby, Peter; Hickman, George; MacKenna, Brian; Tomlinson, Laurie; Ca Green, Amelia; Fisher, Louis; Cockburn, Jonathan; Parry, John; Hester, Frank; Harper, Sam; Bates, Christopher; Evans, Stephen Jw; Solomon, Tom; Andrews, Nick J; Douglas, Ian J; Goldacre, Ben; Smeeth, Liam; McDonald, Helen I; (2022) Safety of COVID-19 vaccination and acute neurological events: A self-controlled case series in England using the OpenSAFELY platform. Vaccine, 40 (32). pp. 4479-4487. ISSN 0264-410X DOI: https://doi.org/10.1016/j.vaccine.2022.06.010

Warren-Gash, Charlotte; Cadogan, Sharon L; Nicholas, Jennifer M; Breuer, Judith M; Shah, Divya; Pearce, Neil; Shiekh, Suhail; Smeeth, Liam; Farlow, Martin R; Mori, Hiroshi; +12 more... Gordon, Brian A; Nuebling, Georg; McDade, Eric; Bateman, Randall J; Schofield, Peter R; Lee, Jae-Hong; Morris, John C; Cash, David M; Fox, Nick C; Ridha, Basil H; Rossor, Martin N; Dominantly Inherited Alzheimer Network; (2022) Herpes simplex virus and rates of cognitive decline or whole brain atrophy in the Dominantly Inherited Alzheimer Network. Annals of Clinical and Translational Neurology, 9 (11). pp. 1727-1738. DOI: https://doi.org/10.1002/acn3.51669

Warren-Gash, Charlotte; Williamson, Elizabeth; Shiekh, Suhail I; Borjas-Howard, James; Pearce, Neil; Breuer, Judith M; Smeeth, Liam; (2022) No evidence that herpes zoster is associated with increased risk of dementia diagnosis. Annals of clinical and translational neurology, 9 (3). pp. 363-374. ISSN 2328-9503 DOI: https://doi.org/10.1002/acn3.51525

Watkins, Sarah Holmes; Ho, Karen; Testa, Christian; Falk, Louise; Soule, Patrice; Nguyen, Linda V; FitzGibbon, Sophie; Slack, Catherine; Chen, Jarvis T; Davey Smith, George; +7 more... De Vivo, Immaculata; Simpkin, Andrew J; Tilling, Kate; Waterman, Pamela D; Krieger, Nancy; Suderman, Matthew; Relton, Caroline; (2022) The impact of low input DNA on the reliability of DNA methylation as measured by the Illumina Infinium MethylationEPIC BeadChip. Epigenetics, 17 (13). pp. 2366-2376. ISSN 1559-2294 DOI: https://doi.org/10.1080/15592294.2022.2123898

Watson-Jones, Deborah; Changalucha, John; Whitworth, Hilary; Pinto, Ligia; Mutani, Paul; Indangasi, Jackton; Kemp, Troy; Hashim, Ramadhan; Kamala, Beatrice; Wiggins, Rebecca; +13 more... Songoro, Twaib; Connor, Nicholas; Mbwanji, Gladys; Pavon, Miquel A; Lowe, Brett; Mmbando, Devis; Kapiga, Saidi; Mayaud, Philippe; de SanJosé, Silvia; Dillner, Joakim; Hayes, Richard J; Lacey, Charles J; Baisley, Kathy; (2022) Immunogenicity and safety of one-dose human papillomavirus vaccine compared with two or three doses in Tanzanian girls (DoRIS): an open-label, randomised, non-inferiority trial. The Lancet Global health, 10 (10). e1473-e1484. ISSN 2214-109X DOI: https://doi.org/10.1016/S2214-109X(22)00309-6

Wielscher, Matthias; Mandaviya, Pooja R; Kuehnel, Brigitte; Joehanes, Roby; Mustafa, Rima; Robinson, Oliver; Zhang, Yan; Bodinier, Barbara; Walton, Esther; Mishra, Pashupati P; +80 more... Schlosser, Pascal; Wilson, Rory; Tsai, Pei-Chien; Palaniswamy, Saranya; Marioni, Riccardo E; Fiorito, Giovanni; Cugliari, Giovanni; Karhunen, Ville; Ghanbari, Mohsen; Psaty, Bruce M; Loh, Marie; Bis, Joshua C; Lehne, Benjamin; Sotoodehnia, Nona; Deary, Ian J; Chadeau-Hyam, Marc; Brody, Jennifer A; Cardona, Alexia; Selvin, Elizabeth; Smith, Alicia K; Miller, Andrew H; Torres, Mylin A; Marouli, Eirini; Gào, Xin; van Meurs, Joyce BJ; Graf-Schindler, Johanna; Rathmann, Wolfgang; Koenig, Wolfgang; Peters, Annette; Weninger, Wolfgang; Farlik, Matthias; Zhang, Tao; Chen, Wei; Xia, Yujing; Teumer, Alexander; Nauck, Matthias; Grabe, Hans J; Doerr, Macus; Lehtimäki, Terho; Guan, Weihua; Milani, Lili; Tanaka, Toshiko; Fisher, Krista; Waite, Lindsay L; Kasela, Silva; Vineis, Paolo; Verweij, Niek; van der Harst, Pim; Iacoviello, Licia; Sacerdote, Carlotta; Panico, Salvatore; Krogh, Vittorio; Tumino, Rosario; Tzala, Evangelia; Matullo, Giuseppe; Hurme, Mikko A; Raitakari, Olli T; Colicino, Elena; Baccarelli, Andrea A; Kähönen, Mika; Herzig, Karl-Heinz; Li, Shengxu; BIOS consortium; Conneely, Karen N; Kooner, Jaspal S; Köttgen, Anna; Heijmans, Bastiaan T; Deloukas, Panos; Relton, Caroline; Ong, Ken K; Bell, Jordana T; Boerwinkle, Eric; Elliott, Paul; Brenner, Hermann; Beekman, Marian; Levy, Daniel; Waldenberger, Melanie; Chambers, John C; Dehghan, Abbas; Järvelin, Marjo-Riitta; (2022) DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases. Nature communications, 13 (1). 2408-. ISSN 2041-1723 DOI: https://doi.org/10.1038/s41467-022-29792-6

Wong, Angel Ys; Tomlinson, Laurie; Brown, Jeremy P; Elson, William; Walker, Alex J; Schultze, Anna; Morton, Caroline E; Evans, David; Inglesby, Peter; MacKenna, Brian; +21 more... Bhaskaran, Krishnan; Rentsch, Christopher T; Powell, Emma; Williamson, Elizabeth; Croker, Richard; Bacon, Seb; Hulme, William; Bates, Chris; Curtis, Helen J; Mehrkar, Amir; Cockburn, Jonathan; McDonald, Helen I; Mathur, Rohini; Wing, Kevin; Forbes, Harriet; Eggo, Rosalind M; Evans, Stephen Jw; Smeeth, Liam; Goldacre, Ben; Douglas, Ian J; (The OpenSAFELY Collaborative); (2022) Association between oral anticoagulants and COVID-19-related outcomes: a population-based cohort study. The British journal of general practice : the journal of the Royal College of General Practitioners, 72 (720). e456-e463. ISSN 0960-1643 DOI: https://doi.org/10.3399/BJGP.2021.0689

Woodhouse, MJ; Aspinall, WP; Sparks, RSJ; Brooks-Pollock, E; Relton, C; (2022) Alternative COVID-19 mitigation measures in school classrooms: analysis using an agent-based model of SARS-CoV-2 transmission. Royal Society open science, 9 (8). 211985-. ISSN 2054-5703 DOI: https://doi.org/10.1098/rsos.211985

Woolford, Stephen J; D'Angelo, Stefania; Mancano, Giulia; Curtis, Elizabeth M; Ashai, Shanze; Shivappa, Nitin; Hébert, James R; Crozier, Sarah R; Phillips, Catherine M; Suderman, Matthew; +4 more... Relton, Caroline L; Cooper, Cyrus; Harvey, Nicholas C; ALPHABET Consortium Investigators; (2022) Associations Between Late Pregnancy Dietary Inflammatory Index (DII) and Offspring Bone Mass: A Meta-Analysis of the Southampton Women's Survey (SWS) and the Avon Longitudinal Study of Parents and Children (ALSPAC). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 37 (8). pp. 1511-1519. ISSN 0884-0431 DOI: https://doi.org/10.1002/jbmr.4623