Racané, Livio; Ptiček, Lucija; Kostrun, Sanja; Raić-Malić, Silvana; Taylor, Martin Craig; Delves, Michael; Alsford, Sam; Olmo, Francisco; Francisco, Amanda Fortes; Kelly, John M; (2023) Bis-6-amidino-benzothiazole Derivative that Cures Experimental Stage 1 African Trypanosomiasis with a Single Dose. Journal of medicinal chemistry, 66 (18). pp. 13043-13057. ISSN 0022-2623 DOI: https://doi.org/10.1021/acs.jmedchem.3c01051

Borg, Yanika; Alsford, Sam; Pavlika, Vasos; Zaikin, Alexei; Nesbeth, Darren N; (2022) Synthetic biology tools for engineering Goodwin oscillation in Trypanosoma brucei brucei. Heliyon, 8 (2). e08891-. ISSN 2405-8440 DOI: https://doi.org/10.1016/j.heliyon.2022.e08891

Davies, Carys; Ooi, Cher-Pheng; Sioutas, Georgios; Hall, Belinda S; Sidhu, Haneesh; Butter, Falk; Alsford, Sam; Wickstead, Bill; Rudenko, Gloria; (2021) TbSAP is a novel chromatin protein repressing metacyclic variant surface glycoprotein expression sites in bloodstream form Trypanosoma brucei. Nucleic Acids Research, 49 (6). pp. 3242-3262. ISSN 0305-1048 DOI: https://doi.org/10.1093/nar/gkab109

Collett, Clare F; Kitson, Carl; Baker, Nicola; Steele-Stallard, Heather B; Santrot, Marie-Victoire; Hutchinson, Sebastian; Horn, David; Alsford, Sam; (2019) Chemogenomic profiling of anti-leishmanial efficacy and resistance in the related kinetoplastid parasite <i>Trypanosoma brucei</i>. DOI: https://doi.org/10.1101/605873

Collett, Clare F; Kitson, Carl; Baker, Nicola; Steele-Stallard, Heather B; Santrot, Marie-Victoire; Hutchinson, Sebastian; Horn, David; Alsford, Sam; (2019) Chemogenomic Profiling of Antileishmanial Efficacy and Resistance in the Related Kinetoplastid Parasite Trypanosoma brucei. Antimicrobial Agents and Chemotherapy, 63 (8). ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.00795-19

Currier, Rachel B; Cooper, Anneli; Burrell-Saward, Hollie; MacLeod, Annette; Alsford, Sam; (2018) Decoding the network of Trypanosoma brucei proteins that determines sensitivity to apolipoprotein-L1. PLoS pathogens, 14 (1). e1006855-. ISSN 1553-7366 DOI: https://doi.org/10.1371/journal.ppat.1006855

Thomas, James A; Baker, Nicola; Hutchinson, Sebastian; Dominicus, Caia; Trenaman, Anna; Glover, Lucy; Alsford, Sam; Horn, David; (2018) Insights into antitrypanosomal drug mode-of-action from cytology-based profiling. PLOS NEGLECTED TROPICAL DISEASES, 12 (11). e0006980-. ISSN 1935-2735 DOI: https://doi.org/10.1371/journal.pntd.0006980

Macedo, Juan P; Currier, Rachel B; Wirdnam, Corina; Horn, David; Alsford, Sam; Rentsch, Doris; (2017) Ornithine uptake and the modulation of drug sensitivity in Trypanosoma brucei. FASEB journal, 31 (10). pp. 4649-4660. ISSN 0892-6638 DOI: https://doi.org/10.1096/fj.201700311R

Meredith, Emma Louise; Kumar, Ambika; Konno, Aya; Szular, Joanna; Alsford, Sam; Seifert, Karin; Horn, David; Wilkinson, Shane R; (2017) Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs. Molecular microbiology, 106 (2). pp. 207-222. ISSN 0950-382X DOI: https://doi.org/10.1111/mmi.13767

Stortz, Jennifer A; Serafim, Tiago D; Alsford, Sam; Wilkes, Jonathan; Fernandez-Cortes, Fernando; Hamilton, Graham; Briggs, Emma; Lemgruber, Leandro; Horn, David; Mottram, Jeremy C; +1 more... McCulloch, Richard; (2017) Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei. PLoS pathogens, 13 (7). e1006477-. ISSN 1553-7366 DOI: https://doi.org/10.1371/journal.ppat.1006477

Glover, Lucy; Hutchinson, Sebastian; Alsford, Sam; Horn, David; (2016) VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes. Proceedings of the National Academy of Sciences of the United States of America, 113 (26). pp. 7225-7230. ISSN 0027-8424 DOI: https://doi.org/10.1073/pnas.1600344113

Maishman, Luke; Obado, Samson O; Alsford, Sam; Bart, Jean-Mathieu; Chen, Wei-Ming; Ratushny, Alexander V; Navarro, Miguel; Horn, David; Aitchison, John D; Chait, Brian T; +2 more... Rout, Michael P; Field, Mark C; (2016) Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression. Nucleic acids research, 44 (22). pp. 10554-10570. ISSN 0305-1048 DOI: https://doi.org/10.1093/nar/gkw751

Alsford, Sam; (2015) Subverting lysosomal function in Trypanosoma brucei. Microbial cell (Graz, Austria), 2 (8). pp. 259-261. ISSN 2311-2638 DOI: https://doi.org/10.15698/mic2015.08.222

Zoltner, Martin; Leung, Ka Fai; Alsford, Sam; Horn, David; Field, Mark C; (2015) Modulation of the Surface Proteome through Multiple Ubiquitylation Pathways in African Trypanosomes. PLoS pathogens, 11 (10). e1005236-. ISSN 1553-7366 DOI: https://doi.org/10.1371/journal.ppat.1005236

Alsford, Sam; (2014) Increased Trypanosoma brucei cathepsin-L activity inhibits human serum-mediated trypanolysis. Microbial cell (Graz, Austria), 1 (8). pp. 270-272. ISSN 2311-2638 DOI: https://doi.org/10.15698/mic2014.08.162

Alsford, Sam; Currier, Rachel B; Guerra-Assunção, José Afonso; Clark, Taane G; Horn, David; (2014) Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei. PLoS pathogens, 10 (5). e1004130-. ISSN 1553-7366 DOI: https://doi.org/10.1371/journal.ppat.1004130

Glover, Lucy; Alsford, Sam; Baker, Nicola; Turner, Daniel J; Sanchez-Flores, Alejandro; Hutchinson, Sebastian; Hertz-Fowler, Christiane; Berriman, Matthew; Horn, David; (2014) Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes. Nature protocols, 10 (1). pp. 106-133. ISSN 1754-2189 DOI: https://doi.org/10.1038/nprot.2015.005 Full text not available from this repository.

Alsford, Sam; Field, Mark C; Horn, David; (2013) Receptor-mediated endocytosis for drug delivery in African trypanosomes: fulfilling Paul Ehrlich's vision of chemotherapy. Trends in parasitology, 29 (5). pp. 207-212. ISSN 1471-4922 DOI: https://doi.org/10.1016/j.pt.2013.03.004 Full text not available from this repository.

Alsford, Sam; Kelly, John M; Baker, Nicola; Horn, David; (2013) Genetic dissection of drug resistance in trypanosomes. Parasitology, 140 (12). pp. 1478-1491. ISSN 0031-1820 DOI: https://doi.org/10.1017/S003118201300022X

Glover, Lucy; Alsford, Sam; Horn, David; (2013) DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes. PLoS pathogens, 9 (3). e1003260-. ISSN 1553-7366 DOI: https://doi.org/10.1371/journal.ppat.1003260

Glover, Lucy; Hutchinson, Sebastian; Alsford, Sam; McCulloch, Richard; Field, Mark C; Horn, David; (2013) Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control. Cellular microbiology, 15 (12). pp. 1984-1993. ISSN 1462-5814 DOI: https://doi.org/10.1111/cmi.12215

Gould, Matthew K; Bachmaier, Sabine; Ali, Juma AM; Alsford, Sam; Tagoe, Daniel NA; Munday, Jane C; Schnaufer, Achim C; Horn, David; Boshart, Michael; de Koning, Harry P; (2013) Cyclic AMP effectors in African trypanosomes revealed by genome-scale RNA interference library screening for resistance to the phosphodiesterase inhibitor CpdA. Antimicrobial agents and chemotherapy, 57 (10). pp. 4882-4893. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.00508-13

Alsford, Sam; Eckert, Sabine; Baker, Nicola; Glover, Lucy; Sanchez-Flores, Alejandro; Leung, Ka Fai; Turner, Daniel J; Field, Mark C; Berriman, Matthew; Horn, David; (2012) High-throughput decoding of antitrypanosomal drug efficacy and resistance. Nature, 482 (7384). pp. 232-236. ISSN 0028-0836 DOI: https://doi.org/10.1038/nature10771

Alsford, Sam; Horn, David; (2012) Cell-cycle-regulated control of VSG expression site silencing by histones and histone chaperones ASF1A and CAF-1b in Trypanosoma brucei. Nucleic acids research, 40 (20). pp. 10150-10160. ISSN 0305-1048 DOI: https://doi.org/10.1093/nar/gks813

Alsford, Sam; duBois, Kelly; Horn, David; Field, Mark C; (2012) Epigenetic mechanisms, nuclear architecture and the control of gene expression in trypanosomes. Expert reviews in molecular medicine, 14. e13-. ISSN 1462-3994 DOI: https://doi.org/10.1017/erm.2012.7 Full text not available from this repository.

DuBois, Kelly N; Alsford, Sam; Holden, Jennifer M; Buisson, Johanna; Swiderski, Michal; Bart, Jean-Mathieu; Ratushny, Alexander V; Wan, Yakun; Bastin, Philippe; Barry, J David; +5 more... Navarro, Miguel; Horn, David; Aitchison, John D; Rout, Michael P; Field, Mark C; (2012) NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functions. PLoS biology, 10 (3). e1001287-. ISSN 1544-9173 DOI: https://doi.org/10.1371/journal.pbio.1001287

Field, Mark C; Horn, David; Alsford, Sam; Koreny, Ludek; Rout, Michael P; (2012) Telomeres, tethers and trypanosomes. Nucleus (Austin, Tex), 3 (6). pp. 478-486. ISSN 1949-1034 DOI: https://doi.org/10.4161/nucl.22167

Alsford, Sam; Horn, David; (2011) Elongator protein 3b negatively regulates ribosomal DNA transcription in african trypanosomes. Molecular and cellular biology, 31 (9). pp. 1822-1832. ISSN 0270-7306 DOI: https://doi.org/10.1128/MCB.01026-10

Alsford, Sam; Turner, Daniel J; Obado, Samson O; Sanchez-Flores, Alejandro; Glover, Lucy; Berriman, Matthew; Hertz-Fowler, Christiane; Horn, David; (2011) High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome. Genome research, 21 (6). pp. 915-924. ISSN 1088-9051 DOI: https://doi.org/10.1101/gr.115089.110

Alsford, Sam; Kemp, Louise E; Kawahara, Taemi; Horn, David; (2010) RNA interference, growth and differentiation appear normal in African trypanosomes lacking Tudor staphylococcal nuclease. Molecular and biochemical parasitology, 174 (1). pp. 70-73. ISSN 0166-6851 DOI: https://doi.org/10.1016/j.molbiopara.2010.06.006

Baker, Nicola; Alsford, Sam; Horn, David; (2010) Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6. Molecular and biochemical parasitology, 176 (1). pp. 55-57. ISSN 0166-6851 DOI: https://doi.org/10.1016/j.molbiopara.2010.11.010

Alsford, Sam; Horn, David; Glover, Lucy; (2009) DNA breaks as triggers for antigenic variation in African trypanosomes. Genome biology, 10 (6). 223-. ISSN 1465-6906 DOI: https://doi.org/10.1186/gb-2009-10-6-223

Alsford, Sam; Horn, David; (2008) Single-locus targeting constructs for reliable regulated RNAi and transgene expression in Trypanosoma brucei. Molecular and biochemical parasitology, 161 (1). pp. 76-79. ISSN 0166-6851 DOI: https://doi.org/10.1016/j.molbiopara.2008.05.006

Kawahara, Taemi; Siegel, T Nicolai; Ingram, Alexandra K; Alsford, Sam; Cross, George AM; Horn, David; (2008) Two essential MYST-family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes. Molecular microbiology, 69 (4). pp. 1054-1068. ISSN 0950-382X DOI: https://doi.org/10.1111/j.1365-2958.2008.06346.x

Alsford, Sam; Horn, David; (2007) RNA polymerase I transcription stimulates homologous recombination in Trypanosoma brucei. Molecular and biochemical parasitology, 153 (1). pp. 77-79. ISSN 0166-6851 DOI: https://doi.org/10.1016/j.molbiopara.2007.01.013

Alsford, Sam; Kawahara, Taemi; Isamah, Cyril; Horn, David; (2007) A sirtuin in the African trypanosome is involved in both DNA repair and telomeric gene silencing but is not required for antigenic variation. Molecular microbiology, 63 (3). pp. 724-736. ISSN 0950-382X DOI: https://doi.org/10.1111/j.1365-2958.2006.05553.x

Glover, Lucy; Alsford, Sam; Beattie, Caroline; Horn, David; (2007) Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrest. Nucleic acids research, 35 (3). pp. 872-880. ISSN 0305-1048 DOI: https://doi.org/10.1093/nar/gkl1100

Alsford, Sam; Glover, Lucy; Horn, David; (2005) Multiplex analysis of RNA interference defects in Trypanosoma brucei. Molecular and biochemical parasitology, 139 (1). pp. 129-132. ISSN 0166-6851 DOI: https://doi.org/10.1016/j.molbiopara.2004.11.001

Alsford, Sam; Kawahara, Taemi; Glover, Lucy; Horn, David; (2005) Tagging a T. brucei RRNA locus improves stable transfection efficiency and circumvents inducible expression position effects. Molecular and biochemical parasitology, 144 (2). pp. 142-148. ISSN 0166-6851 DOI: https://doi.org/10.1016/j.molbiopara.2005.08.009

Alsford, Sam; Horn, David; (2004) Trypanosomatid histones. Molecular microbiology, 53 (2). pp. 365-372. ISSN 0950-382X DOI: https://doi.org/10.1111/j.1365-2958.2004.04151.x Full text not available from this repository.

Alsford, NS; Navarro, M; Jamnadass, HR; Dunbar, H; Ackroyd, M; Murphy, NB; Gull, K; Ersfeld, K; (2003) The identification of circular extrachromosomal DNA in the nuclear genome of Trypanosoma brucei. Molecular microbiology, 47 (2). pp. 277-289. ISSN 0950-382X DOI: https://doi.org/10.1046/j.1365-2958.2003.03266.x Full text not available from this repository.

Alsford, S; Wickstead, B; Ersfeld, K; Gull, K; (2001) Diversity and dynamics of the minichromosomal karyotype in Trypanosoma brucei. Molecular and biochemical parasitology, 113 (1). pp. 79-88. ISSN 0166-6851 DOI: https://doi.org/10.1016/s0166-6851(00)00388-1 Full text not available from this repository.