Khan, Archie A; Langston, Harry C; Walsh, Louis; Roscoe, Rebecca; Jayawardhana, Shiromani; Francisco, Amanda Fortes; Taylor, Martin C; McCann, Conor J; Kelly, John M; Lewis, Michael D; (2024) Enteric nervous system regeneration and functional cure of experimental digestive Chagas disease with trypanocidal chemotherapy. Nature Communications, 15 (1). 4400-. ISSN 2041-1723 DOI: https://doi.org/10.1038/s41467-024-48749-5

Khan, Archie A; Taylor, Martin C; Fortes Francisco, Amanda; Jayawardhana, Shiromani; Atherton, Richard L; Olmo, Francisco; Lewis, Michael D; Kelly, John M; (2024) Animal models for exploring Chagas disease pathogenesis and supporting drug discovery. Clinical microbiology reviews, 37 (4). e0015523-. ISSN 0893-8512 DOI: https://doi.org/10.1128/cmr.00155-23

Langston, H; (2024) Study of the Determinants of Enteric Neuropathy in Experimental Chagas Disease. PhD thesis, London School of Hygiene & Tropical Medicine. DOI: https://doi.org/10.17037/PUBS.04673217

Langston, Harry; Fortes Francisco, Amanda; Doidge, Ciaran; Roberts, Chrissy H; Khan, Archie A; Jayawardhana, Shiromani; Taylor, Martin C; Kelly, John M; Lewis, Michael D; (2024) Dynamics of Trypanosoma cruzi infection in hamsters and novel association with progressive motor dysfunction. PLoS neglected tropical diseases, 18 (6). e0012278-. ISSN 1935-2727 DOI: https://doi.org/10.1371/journal.pntd.0012278

Li, Yutong; Cardoso-Silva, Jonathan; Kelly, John M; Delves, Michael J; Furnham, Nicholas; Papageorgiou, Lazaros G; Tsoka, Sophia; (2024) Optimisation-based modelling for explainable lead discovery in malaria. Artificial intelligence in medicine, 147. 102700-. ISSN 0933-3657 DOI: https://doi.org/10.1016/j.artmed.2023.102700

Olmo, Francisco; Jayawardhana, Shiromani; Khan, Archie A; Langston, Harry C; Francisco, Amanda Fortes; Atherton, Richard L; Ward, Alex I; Taylor, Martin C; Kelly, John M; Lewis, Michael D; (2024) A panel of phenotypically and genotypically diverse bioluminescent:fluorescent Trypanosoma cruzi strains as a resource for Chagas disease research. PLoS Neglected Tropical Diseases, 18 (5). e0012106-. ISSN 1935-2727 DOI: https://doi.org/10.1371/journal.pntd.0012106

Trometer, Nathan; Pecourneau, Jérémy; Feng, Liwen; Navarro-Huerta, José A; Lazarin-Bidóia, Danielle; de Oliveira Silva Lautenschlager, Sueli; Maes, Louis; Fortes Francisco, Amanda; Kelly, John M; Meunier, Brigitte; +4 more... Cal, Monica; Mäser, Pascal; Kaiser, Marcel; Davioud-Charvet, Elisabeth; (2024) Synthesis and Anti-Chagas Activity Profile of a Redox-Active Lead 3-Benzylmenadione Revealed by High-Content Imaging. ACS Infectious Diseases, 10 (5). pp. 1808-1838. ISSN 2373-8227 DOI: https://doi.org/10.1021/acsinfecdis.4c00137

Francisco, Amanda F; Chen, Gong; Wang, Wen; Sykes, Melissa L; Escudié, Fanny; Scandale, Ivan; Olmo, Francisco; Shackleford, David M; Zulfiqar, Bilal; Kratz, Jadel M; +7 more... Pham, Thao; Saunders, Jessica; Hu, Meiyu; Avery, Vicky M; Charman, Susan A; Kelly, John M; Chatelain, Eric; (2023) Preclinical data do not support the use of amiodarone or dronedarone as antiparasitic drugs for Chagas disease at the approved human dosing regimen. Frontiers in tropical diseases, 4. DOI: https://doi.org/10.3389/fitd.2023.1254061

Francisco, Amanda Fortes; Sousa, Giovane R; Vaughan, Mhairi; Langston, Harry; Khan, Archie; Jayawardhana, Shiromani; Taylor, Martin C; Lewis, Michael D; Kelly, John M; (2023) Cardiac Abnormalities in a Predictive Mouse Model of Chagas Disease. Pathogens, 12 (11). p. 1364. DOI: https://doi.org/10.3390/pathogens12111364

González, Silvia; Wall, Richard J; Thomas, John; Braillard, Stephanie; Brunori, Gino; Camino Díaz, Isabel; Cantizani, Juan; Carvalho, Sandra; Castañeda Casado, Pablo; Chatelain, Eric; +20 more... Cotillo, Ignacio; Fiandor, Jose M; Francisco, Amanda Fortes; Grimsditch, David; Keenan, Martine; Kelly, John M; Kessler, Albane; Luise, Chiara; Lyon, Jon J; MacLean, Lorna; Marco, Maria; Martin, J Julio; Martinez Martinez, Maria S; Paterson, Christy; Read, Kevin D; Santos-Villarejo, Angel; Zuccotto, Fabio; Wyllie, Susan; Miles, Tim J; De Rycker, Manu; (2023) Short-course combination treatment for experimental chronic Chagas disease. Science translational medicine, 15 (726). eadg8105-. ISSN 1946-6234 DOI: https://doi.org/10.1126/scitranslmed.adg8105

Jayawardhana, Shiromani; Ward, Alexander I; Francisco, Amanda F; Lewis, Michael D; Taylor, Martin C; Kelly, John M; Olmo, Francisco; (2023) Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice. PLoS Pathogens, 19 (11). e1011627-. ISSN 1553-7366 DOI: https://doi.org/10.1371/journal.ppat.1011627

Pardali, Vasiliki; Giannakopoulou, Erofili; Mpekoulis, George; Tsopela, Vassilina; Panos, Georgios; Taylor, Martin C; Kelly, John M; Vassilaki, Niki; Zoidis, Grigoris; (2023) Novel Lipophilic Hydroxamates Based on Spirocarbocyclic Hydantoin Scaffolds with Potent Antiviral and Trypanocidal Activity. Pharmaceuticals, 16 (7). p. 1046. ISSN 1424-8247 DOI: https://doi.org/10.3390/ph16071046

Racané, Livio; Ptiček, Lucija; Kostrun, Sanja; Raić-Malić, Silvana; Taylor, Martin Craig; Delves, Michael; Alsford, Sam; Olmo, Francisco; Francisco, Amanda Fortes; Kelly, John M; (2023) Bis-6-amidino-benzothiazole Derivative that Cures Experimental Stage 1 African Trypanosomiasis with a Single Dose. Journal of medicinal chemistry, 66 (18). pp. 13043-13057. ISSN 0022-2623 DOI: https://doi.org/10.1021/acs.jmedchem.3c01051

Racané, Livio; Zlatić, Katarina; Cindrić, Maja; Mehić, Emina; Karminski-Zamola, Grace; Taylor, Martin C; Kelly, John M; Malić, Silvana Raić; Stojković, Marijana Radić; Kralj, Marijeta; +1 more... Hranjec, Marijana; (2023) Synthesis and Biological Activity of 2-Benzo[b]thienyl and 2-Bithienyl Amidino-Substituted Benzothiazole and Benzimidazole Derivatives. ChemMedChem, 18 (18). e202300261-. ISSN 1860-7179 DOI: https://doi.org/10.1002/cmdc.202300261

Rao, Srinivasa PS; Gould, Matthew K; Noeske, Jonas; Saldivia, Manuel; Jumani, Rajiv S; Ng, Pearly S; René, Olivier; Chen, Yen-Liang; Kaiser, Marcel; Ritchie, Ryan; +32 more... Francisco, Amanda Fortes; Johnson, Nila; Patra, Debjani; Cheung, Harry; Deniston, Colin; Schenk, Andreas D; Cortopassi, Wilian A; Schmidt, Remo S; Wiedemar, Natalie; Thomas, Bryanna; Palkar, Rima; Ghafar, Nahdiyah A; Manoharan, Vanessa; Luu, Catherine; Gable, Jonathan E; Wan, Kah Fei; Myburgh, Elmarie; Mottram, Jeremy C; Barnes, Whitney; Walker, John; Wartchow, Charles; Aziz, Natasha; Osborne, Colin; Wagner, Juergen; Sarko, Christopher; Kelly, John M; Manjunatha, Ujjini H; Mäser, Pascal; Jiricek, Jan; Lakshminarayana, Suresh B; Barrett, Michael P; Diagana, Thierry T; (2023) Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections. Science, 380 (6652). pp. 1349-1356. ISSN 0036-8075 DOI: https://doi.org/10.1126/science.adh0614

Roscoe, RB; (2023) Characterising kinetoplastid pantothenate kinase, a multifunctional enzyme of the CoA biosynthesis pathway. PhD thesis, London School of Hygiene & Tropical Medicine. DOI: https://doi.org/10.17037/PUBS.04670994

Tawaraishi, Taisuke; Ochida, Atsuko; Akao, Yuichiro; Itono, Sachiko; Kamaura, Masahiro; Akther, Thamina; Shimada, Mitsuyuki; Canan, Stacie; Chowdhury, Sanjoy; Cao, Yafeng; +21 more... Condroski, Kevin; Engkvist, Ola; Francisco, Amanda; Ghosh, Sunil; Kaki, Rina; Kelly, John M; Kimura, Chiaki; Kogej, Thierry; Nagaoka, Kazuya; Naito, Akira; Pairaudeau, Garry; Radu, Constantin; Roberts, Ieuan; Shum, David; Watanabe, Nao-Aki; Xie, Huanxu; Yonezawa, Shuji; Yoshida, Osamu; Yoshida, Ryu; Mowbray, Charles; Perry, Benjamin; (2023) Collaborative Virtual Screening Identifies a 2-Aryl-4-aminoquinazoline Series with Efficacy in an In Vivo Model of Trypanosoma cruzi Infection. Journal of medicinal chemistry, 66 (2). pp. 1221-1238. ISSN 0022-2623 DOI: https://doi.org/10.1021/acs.jmedchem.2c00775

Abacha, Yabalu Z; Forkuo, Arnold Donkor; Gbedema, Stephen Y; Mittal, Nimisha; Ottilie, Sabine; Rocamora, Frances; Winzeler, Elizabeth A; van Schalkwyk, Donelly A; Kelly, John M; Taylor, Martin C; +9 more... Reader, Janette; Birkholtz, Lyn-Marie; Lisgarten, David R; Cockcroft, Jeremy K; Lisgarten, John N; Palmer, Rex A; Talbert, Rosemary C; Shnyder, Steven D; Wright, Colin W; (2022) Semi-Synthetic Analogues of Cryptolepine as a Potential Source of Sustainable Drugs for the Treatment of Malaria, Human African Trypanosomiasis, and Cancer. Frontiers in Pharmacology, 13. 875647-. ISSN 1663-9812 DOI: https://doi.org/10.3389/fphar.2022.875647

Ang, Chee Wei; Lee, Brendon M; Jackson, Colin J; Wang, Yuehong; Franzblau, Scott G; Francisco, Amanda F; Kelly, John M; Bernhardt, Paul V; Tan, Lendl; West, Nicholas P; +6 more... Sykes, Melissa L; Hinton, Alexandra O; Bolisetti, Raghu; Avery, Vicky M; Cooper, Matthew A; Blaskovich, Mark AT; (2022) Nitroimidazopyrazinones with Oral Activity against Tuberculosis and Chagas Disease in Mouse Models of Infection. Journal of Medicinal Chemistry, 65 (19). pp. 13125-13142. ISSN 0022-2623 DOI: https://doi.org/10.1021/acs.jmedchem.2c00972

Foscolos, Angeliki Sofia; Tsotinis, Andrew; Taylor, Martin C; Kelly, John M; Papanastasiou, Ioannis P; (2022) Probing Adamantane Arylhydroxamic Acids against Trypanosoma brucei and Trypanosoma cruzi. Molbank, 2022 (2). M1363-M1363. ISSN 1422-8599 DOI: https://doi.org/10.3390/m1363

Francisco, Amanda Fortes; Saade, Ursula; Jayawardhana, Shiromani; Pottel, Hans; Scandale, Ivan; Chatelain, Eric; Liehl, Peter; Kelly, John M; Zrein, Maan; (2022) Comparing in vivo bioluminescence imaging and the Multi-Cruzi immunoassay platform to develop improved Chagas disease diagnostic procedures and biomarkers for monitoring parasitological cure. PLoS neglected tropical diseases, 16 (10). e0010827-. ISSN 1935-2727 DOI: https://doi.org/10.1371/journal.pntd.0010827

Ward, Alexander I; Lewis, Michael D; Taylor, Martin C; Kelly, John M; (2022) Incomplete Recruitment of Protective T Cells Is Associated with Trypanosoma cruzi Persistence in the Mouse Colon. Infection and Immunity, 90 (2). e0038221-. ISSN 0019-9567 DOI: https://doi.org/10.1128/IAI.00382-21

Beltran-Hortelano, Iván; Atherton, Richard L; Rubio-Hernández, Mercedes; Sanz-Serrano, Julen; Alcolea, Verónica; Kelly, John M; Pérez-Silanes, Silvia; Olmo, Francisco; (2021) Design and synthesis of Mannich base-type derivatives containing imidazole and benzimidazole as lead compounds for drug discovery in Chagas Disease. European journal of medicinal chemistry, 223. 113646-. ISSN 0223-5234 DOI: https://doi.org/10.1016/j.ejmech.2021.113646

Khan, Archie A; Langston, Harry C; Costa, Fernanda C; Olmo, Francisco; Taylor, Martin C; McCann, Conor J; Kelly, John M; Lewis, Michael D; (2021) Local association of Trypanosoma cruzi chronic infection foci and enteric neuropathic lesions at the tissue micro-domain scale. PLoS pathogens, 17 (8). e1009864-. ISSN 1553-7366 DOI: https://doi.org/10.1371/journal.ppat.1009864

Racané, Livio; Rep, Valentina; Kraljević Pavelić, Sandra; Grbčić, Petra; Zonjić, Iva; Radić Stojković, Marijana; Taylor, Martin C; Kelly, John M; Raić-Malić, Silvana; (2021) Synthesis, antiproliferative and antitrypanosomal activities, and DNA binding of novel 6-amidino-2-arylbenzothiazoles. Journal of Enzyme Inhibition and Medicinal Chemistry, 36 (1). pp. 1952-1967. ISSN 1475-6366 DOI: https://doi.org/10.1080/14756366.2021.1959572

Scarim, Cauê Benito; Olmo, Francisco; Ferreira, Elizabeth Igne; Chin, Chung Man; Kelly, John M; Fortes Francisco, Amanda; (2021) Image-Based In Vitro Screening Reveals the Trypanostatic Activity of Hydroxymethylnitrofurazone against Trypanosoma cruzi. International Journal of Molecular Sciences, 22 (13). p. 6930. ISSN 1661-6596 DOI: https://doi.org/10.3390/ijms22136930

Ward, A; (2021) Trypanosoma cruzi : Where is it? Does it ever sleep? Why is a sterile outcome rarely achieved? PhD (research paper style) thesis, London School of Hygiene & Tropical Medicine. DOI: https://doi.org/10.17037/PUBS.04661782

Fesser, Anna F; Braissant, Olivier; Olmo, Francisco; Kelly, John M; Mäser, Pascal; Kaiser, Marcel; (2020) Non-invasive monitoring of drug action: A new live in vitro assay design for Chagas' disease drug discovery. PLOS NEGLECTED TROPICAL DISEASES, 14 (7). e0008487-. ISSN 1935-2735 DOI: https://doi.org/10.1371/journal.pntd.0008487

Francisco, Amanda F; Jayawardhana, Shiromani; Olmo, Francisco; Lewis, Michael D; Wilkinson, Shane R; Taylor, Martin C; Kelly, John M; (2020) Challenges in Chagas Disease Drug Development. MOLECULES, 25 (12). p. 2799. ISSN 1420-3049 DOI: https://doi.org/10.3390/molecules25122799

Mann, GS; (2020) Exploring the Potential of Vaccination to Combat Trypanosoma cruzi Infection using Bioluminescent Imaging. PhD (research paper style) thesis, London School of Hygiene & Tropical Medicine. DOI: https://doi.org/10.17037/PUBS.04655803

Mann, Gurdip Singh; Francisco, Amanda F; Jayawardhana, Shiromani; Taylor, Martin C; Lewis, Michael D; Olmo, Francisco; de Freitas, Elisangela Oliveira; Leoratti, Fabiana MS; López-Camacho, Cesar; Reyes-Sandoval, Arturo; +1 more... Kelly, John M; (2020) Drug-cured experimental Trypanosoma cruzi infections confer long-lasting and cross-strain protection. PLoS neglected tropical diseases, 14 (4). e0007717-. ISSN 1935-2727 DOI: https://doi.org/10.1371/journal.pntd.0007717

Pardali, Vasiliki; Giannakopoulou, Erofili; Balourdas, Dimitrios-Ilias; Myrianthopoulos, Vassilios; Taylor, Martin C; Šekutor, Marina; Mlinarić-Majerski, Kata; Kelly, John M; Zoidis, Grigoris; (2020) Lipophilic Guanylhydrazone Analogues as Promising Trypanocidal Agents: An Extended SAR Study. CURRENT PHARMACEUTICAL DESIGN, 26 (8). pp. 838-866. ISSN 1381-6128 DOI: https://doi.org/10.2174/1381612826666200210150127

Popov, Andrea Bistrović; Krstulović, Luka; Koštrun, Sanja; Jelić, Dubravko; Bokulić, Ana; Stojković, Marijana Radić; Zonjić, Iva; Taylor, Martin C; Kelly, John M; Bajić, Miroslav; +1 more... Raić-Malić, Silvana; (2020) Design, synthesis, antitrypanosomal activity, DNA/RNA binding and in vitro ADME profiling of novel imidazoline-substituted 2-arylbenzimidazoles. European journal of medicinal chemistry, 207. 112802-. ISSN 0223-5234 DOI: https://doi.org/10.1016/j.ejmech.2020.112802

Taylor, Martin C; Ward, Alexander I; Olmo, Francisco; Francisco, Amanda F; Jayawardhana, Shiromani; Costa, Fernanda C; Lewis, Michael D; Kelly, John M; (2020) Bioluminescent:Fluorescent Trypanosoma cruzi Reporter Strains as Tools for Exploring Chagas Disease Pathogenesis and Drug Activity. Current pharmaceutical design, 27 (14). pp. 1733-1740. ISSN 1381-6128 DOI: https://doi.org/10.2174/1381612826666201124113214

Taylor, Martin C; Ward, Alexander; Olmo, Francisco; Jayawardhana, Shiromani; Francisco, Amanda F; Lewis, Michael D; Kelly, John M; (2020) Intracellular DNA replication and differentiation of Trypanosoma cruzi is asynchronous within individual host cells in vivo at all stages of infection. PLoS neglected tropical diseases, 14 (3). e0008007-. ISSN 1935-2727 DOI: https://doi.org/10.1371/journal.pntd.0008007

Thompson, Andrew M; O'Connor, Patrick D; Marshall, Andrew J; Francisco, Amanda F; Kelly, John M; Riley, Jennifer; Read, Kevin D; Perez, Catherine J; Cornwall, Scott; Thompson, RC Andrew; +8 more... Keenan, Martine; White, Karen L; Charman, Susan A; Zulfiqar, Bilal; Sykes, Melissa L; Avery, Vicky M; Chatelain, Eric; Denny, William A; (2020) Re-evaluating pretomanid analogues for Chagas disease: Hit-to-lead studies reveal both in vitro and in vivo trypanocidal efficacy. European journal of medicinal chemistry, 207 (112849). 112849-. ISSN 0223-5234 DOI: https://doi.org/10.1016/j.ejmech.2020.112849

Ward, Alexander I; Lewis, Michael D; Khan, Archie A; McCann, Conor J; Francisco, Amanda F; Jayawardhana, Shiromani; Taylor, Martin C; Kelly, John M; (2020) In Vivo Analysis of Trypanosoma cruzi Persistence Foci at Single-Cell Resolution. mBio, 11 (4). pp. 1-13. ISSN 2150-7511 DOI: https://doi.org/10.1128/mBio.01242-20

Ward, Alexander I; Olmo, Francisco; Atherton, Richard L; Taylor, Martin C; Kelly, John M; (2020) Trypanosoma cruzi amastigotes that persist in the colon during chronic stage murine infections have a reduced replication rate. OPEN BIOLOGY, 10 (12). 200261-. ISSN 2046-2441 DOI: https://doi.org/10.1098/rsob.200261

Foscolos, Angeliki-Sofia; Papanastasiou, Ioannis; Tsotinis, Andrew; Taylor, Martin C; Kelly, John M; (2019) Synthesis and Evaluation of Nifurtimox-Adamantane Adducts with Trypanocidal Activity. ChemMedChem, 14 (13). pp. 1227-1231. ISSN 1860-7179 DOI: https://doi.org/10.1002/cmdc.201900165

Fytas, George; Zoidis, Grigoris; Taylor, Martin C; Kelly, John M; Tsatsaroni, Alexandra; Tsotinis, Andrew; (2019) Novel 2,6-diketopiperazine-derived acetohydroxamic acids as promising anti-Trypanosoma brucei agents. FUTURE MEDICINAL CHEMISTRY, 11 (11). pp. 1259-1266. ISSN 1756-8919 DOI: https://doi.org/10.4155/fmc-2018-0599

Georgiadis, Markos-Orestis; Kourbeli, Violeta; Ioannidou, Vaya; Karakitsios, Evangelos; Papanastasiou, Ioannis; Tsotinis, Andrew; Komiotis, Dimitri; Vocat, Anthony; Cole, Stewart T; Taylor, Martin C; +1 more... Kelly, John M; (2019) Synthesis of diphenoxyadamantane alkylamines with pharmacological interest. Bioorganic & medicinal chemistry letters, 29 (11). pp. 1278-1281. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2019.04.010

Georgiadis, Markos-Orestis; Kourbeli, Violeta; Papanastasiou, Ioannis P; Tsotinis, Andrew; Taylor, Martin C; Kelly, John M; (2019) Synthesis and evaluation of novel 2,4-disubstituted arylthiazoles against T. brucei. RSC Medicinal Chemistry, 11 (1). pp. 72-84. DOI: https://doi.org/10.1039/c9md00478e

Giannakopoulou, Erofili; Pardali, Vasiliki; Frakolaki, Efseveia; Siozos, Vasileios; Myrianthopoulos, Vassilios; Mikros, Emmanuel; Taylor, Martin C; Kelly, John M; Vassilaki, Niki; Zoidis, Grigoris; (2019) Scaffold hybridization strategy towards potent hydroxamate-based inhibitors of Flaviviridae viruses and Trypanosoma species. MEDCHEMCOMM, 10 (6). pp. 991-1006. ISSN 2040-2503 DOI: https://doi.org/10.1039/c9md00200f

Hennig, K; Abi-Ghanem, J; Bunescu, A; Meniche, X; Biliaut, E; Ouattara, AD; Lewis, MD; Kelly, JM; Braillard, S; Courtemanche, G; +2 more... Chatelain, E; Béquet, F; (2019) Metabolomics, lipidomics and proteomics profiling of myoblasts infected with Trypanosoma cruzi after treatment with different drugs against Chagas disease. METABOLOMICS, 15 (9). 117-. ISSN 1573-3882 DOI: https://doi.org/10.1007/s11306-019-1583-5

Popov, A Bistrović; Stolić, I; Krstulović, L; Taylor, MC; Kelly, JM; Tomić, S; Tumir, L; Bajić, M; Raić-Malić, S; (2019) Novel symmetric bis-benzimidazoles: Synthesis, DNA/RNA binding and antitrypanosomal activity. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 173. pp. 63-75. ISSN 0223-5234 DOI: https://doi.org/10.1016/j.ejmech.2019.04.007

Rao, Srinivasa PS; Barrett, Michael P; Dranoff, Glenn; Faraday, Christopher J; Gimpelewicz, Claudio R; Hailu, Asrat; Jones, Catherine L; Kelly, John M; Lazdins-Helds, Janis K; Mäser, Pascal; +9 more... Mengel, Jose; Mottram, Jeremy C; Mowbray, Charles E; Sacks, David L; Scott, Phillip; Späth, Gerald F; Tarleton, Rick L; Spector, Jonathan M; Diagana, Thierry T; (2019) Drug Discovery for Kinetoplastid Diseases: Future Directions. ACS INFECTIOUS DISEASES, 5 (2). pp. 152-157. ISSN 2373-8227 DOI: https://doi.org/10.1021/acsinfecdis.8b00298

Taylor, Martin C; Francisco, Amanda F; Jayawardhana, Shiromani; Mann, Gurdip Singh; Ward, Alexander I; Olmo, Francisco; Lewis, Michael D; Kelly, John M; (2019) Exploiting Genetically Modified Dual-Reporter Strains to Monitor Experimental Trypanosoma cruzi Infections and Host-Parasite Interactions. Springer New York, pp. 147-163. ISBN 9781493991471 DOI: https://doi.org/10.1007/978-1-4939-9148-8_11

Adjogatse, Eyram; Erskine, Peter; Wells, Stephen A; Kelly, John M; Wilden, Jonathan D; Chan, AW Edith; Selwood, David; Coker, Alun; Wood, Steve; Cooper, Jonathan B; (2018) Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations. Acta crystallographica Section D, Structural biology, 74 (Pt 9). pp. 861-876. ISSN 2059-7983 DOI: https://doi.org/10.1107/S2059798318009208

Bistrović, Andrea; Krstulović, Luka; Stolić, Ivana; Drenjančević, Domagoj; Talapko, Jasminka; Taylor, Martin C; Kelly, John M; Bajić, Miroslav; Raić-Malić, Silvana; (2018) Synthesis, anti-bacterial and anti-protozoal activities of amidinobenzimidazole derivatives and their interactions with DNA and RNA. Journal of enzyme inhibition and medicinal chemistry, 33 (1). pp. 1323-1334. ISSN 1475-6366 DOI: https://doi.org/10.1080/14756366.2018.1484733

Costa, Fernanda Cristina; Francisco, Amanda Fortes; Jayawardhana, Shiromani; Calderano, Simone Guedes; Lewis, Michael D; Olmo, Francisco; Beneke, Tom; Gluenz, Eva; Sunter, Jack; Dean, Samuel; +2 more... Kelly, John Morrison; Taylor, Martin Craig; (2018) Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping. PLoS neglected tropical diseases, 12 (4). e0006388-. ISSN 1935-2727 DOI: https://doi.org/10.1371/journal.pntd.0006388

Francisco, Amanda Fortes; Jayawardhana, Shiromani; Taylor, Martin C; Lewis, Michael D; Kelly, John M; (2018) Assessing the Effectiveness of Curative Benznidazole Treatment in Preventing Chronic Cardiac Pathology in Experimental Models of Chagas Disease. Antimicrobial agents and chemotherapy, 62 (10). ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.00832-18

Ghashghaei, Ouldouz; Kielland, Nicola; Revés, Marc; Taylor, Martin C; Kelly, John M; Di Pietro, Ornella; Muñoz-Torrero, Diego; Pérez, Belén; Lavilla, Rodolfo; (2018) Tetrasubstituted Imidazolium Salts as Potent Antiparasitic Agents against African and American Trypanosomiases. Molecules (Basel, Switzerland), 23 (1). p. 177. ISSN 1420-3049 DOI: https://doi.org/10.3390/molecules23010177

Lewis, Michael D; Francisco, Amanda F; Jayawardhana, Shiromani; Langston, Harry; Taylor, Martin C; Kelly, John M; (2018) Imaging the development of chronic Chagas disease after oral transmission. Scientific reports, 8 (1). 11292-. ISSN 2045-2322 DOI: https://doi.org/10.1038/s41598-018-29564-7

Olmo, Francisco; Costa, Fernanda C; Mann, Gurdip Singh; Taylor, Martin C; Kelly, John M; (2018) Optimising genetic transformation of Trypanosoma cruzi using hydroxyurea-induced cell-cycle synchronisation. Molecular and biochemical parasitology, 226. pp. 34-36. ISSN 0166-6851 DOI: https://doi.org/10.1016/j.molbiopara.2018.07.002

Brand, Stephen; Ko, Eun Jung; Viayna, Elisabet; Thompson, Stephen; Spinks, Daniel; Thomas, Michael; Sandberg, Lars; Francisco, Amanda F; Jayawardhana, Shiromani; Smith, Victoria C; +26 more... Jansen, Chimed; De Rycker, Manu; Thomas, John; MacLean, Lorna; Osuna-Cabello, Maria; Riley, Jennifer; Scullion, Paul; Stojanovski, Laste; Simeons, Frederick RC; Epemolu, Ola; Shishikura, Yoko; Crouch, Sabrinia D; Bakshi, Tania S; Nixon, Christopher J; Reid, Iain H; Hill, Alan P; Underwood, Tim Z; Hindley, Sean J; Robinson, Sharon A; Kelly, John M; Fiandor, Jose M; Wyatt, Paul G; Marco, Maria; Miles, Timothy J; Read, Kevin D; Gilbert, Ian H; (2017) Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi. Journal of medicinal chemistry, 60 (17). pp. 7284-7299. ISSN 0022-2623 DOI: https://doi.org/10.1021/acs.jmedchem.7b00463

Campos, Mônica C; Phelan, Jody; Francisco, Amanda F; Taylor, Martin C; Lewis, Michael D; Pain, Arnab; Clark, Taane G; Kelly, John M; (2017) Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole. Scientific reports, 7 (1). 14407-. ISSN 2045-2322 DOI: https://doi.org/10.1038/s41598-017-14986-6

Francisco, Amanda F; Jayawardhana, Shiromani; Lewis, Michael D; Taylor, Martin C; Kelly, John M; (2017) Biological factors that impinge on Chagas disease drug development. Parasitology, 144 (14). pp. 1871-1880. ISSN 0031-1820 DOI: https://doi.org/10.1017/S0031182017001469

Zoidis, Grigoris; Tsotinis, Andrew; Tsatsaroni, Alexandra; Taylor, Martin C; Kelly, John M; Efstathiou, Antonia; Smirlis, Despina; Fytas, George; (2017) Lipophilic conformationally constrained spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acid analogues as trypanocidal and leishmanicidal agents: An extended SAR study. Chemical biology & drug design, 91 (2). pp. 408-421. ISSN 1747-0277 DOI: https://doi.org/10.1111/cbdd.13088

Francisco, Amanda Fortes; Jayawardhana, Shiromani; Lewis, Michael D; White, Karen L; Shackleford, David M; Chen, Gong; Saunders, Jessica; Osuna-Cabello, Maria; Read, Kevin D; Charman, Susan A; +2 more... Chatelain, Eric; Kelly, John M; (2016) Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage. Scientific reports, 6 (1). 35351-. ISSN 2045-2322 DOI: https://doi.org/10.1038/srep35351

Kishore, Kranti G; Ghashghaei, Ouldouz; Estarellas, Carolina; Mestre, M Mar; Monturiol, Cristina; Kielland, Nicola; Kelly, John M; Francisco, Amanda Fortes; Jayawardhana, Shiromani; Muñoz-Torrero, Diego; +4 more... Pérez, Belén; Luque, F Javier; Gámez-Montaño, Rocío; Lavilla, Rodolfo; (2016) Insertion of Isocyanides into N-Si Bonds: Multicomponent Reactions with Azines Leading to Potent Antiparasitic Compounds. Angewandte Chemie (International ed in English), 55 (31). pp. 8994-8998. ISSN 1433-7851 DOI: https://doi.org/10.1002/anie.201604109

Kishore, Kranti G; Ghashghaei, Ouldouz; Estarellas, Carolina; Mestre, M Mar; Monturiol, Cristina; Kielland, Nicola; Kelly, John M; Francisco, Amanda Fortes; Jayawardhana, Shiromani; Muñoz-Torrero, Diego; +4 more... Pérez, Belén; Luque, F Javier; Gámez-Montaño, Rocío; Lavilla, Rodolfo; (2016) Insertion of Isocyanides into N-Si Bonds: Multicomponent Reactions with Azines Leading to Potent Antiparasitic Compounds. Angewandte Chemie, 55 (31). pp. 8994-8998. ISSN 0044-8249 DOI: https://doi.org/10.1002/anie.201604109

Lewis, Michael D; Francisco, Amanda Fortes; Taylor, Martin C; Jayawardhana, Shiromani; Kelly, John M; (2016) Host and parasite genetics shape a link between Trypanosoma cruzi infection dynamics and chronic cardiomyopathy. Cellular microbiology, 18 (10). pp. 1429-1443. ISSN 1462-5814 DOI: https://doi.org/10.1111/cmi.12584

Lewis, Michael D; Kelly, John M; (2016) Putting Infection Dynamics at the Heart of Chagas Disease. Trends in parasitology, 32 (11). pp. 899-911. ISSN 1471-4922 DOI: https://doi.org/10.1016/j.pt.2016.08.009

Sola, Irene; Artigas, Albert; Taylor, Martin C; Pérez-Areales, F Javier; Viayna, Elisabet; Clos, M Victòria; Pérez, Belén; Wright, Colin W; Kelly, John M; Muñoz-Torrero, Diego; (2016) Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents. Bioorganic & medicinal chemistry, 24 (21). pp. 5162-5171. ISSN 0968-0896 DOI: https://doi.org/10.1016/j.bmc.2016.08.036

Campos, MCO; Leon, LL; Taylor, MC; Kelly, JM; (2015) "Benznidazole-resistance in Trypanosoma cruzi: Evidence that distinct mechanisms can act in concert'' [Mol. Biochem. Parasit. (2014) 193, 17-19]. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 201 (1). 83-. ISSN 0166-6851 DOI: https://doi.org/10.1016/j.molbiopara.2015.05.006

Di Pietro, Ornella; Vicente-García, Esther; Taylor, Martin C; Berenguer, Diana; Viayna, Elisabet; Lanzoni, Anna; Sola, Irene; Sayago, Helena; Riera, Cristina; Fisa, Roser; +5 more... Clos, M Victòria; Pérez, Belén; Kelly, John M; Lavilla, Rodolfo; Muñoz-Torrero, Diego; (2015) Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity. European journal of medicinal chemistry, 105. pp. 120-137. ISSN 0223-5234 DOI: https://doi.org/10.1016/j.ejmech.2015.10.007

Francisco, Amanda Fortes; Lewis, Michael D; Jayawardhana, Shiromani; Taylor, Martin C; Chatelain, Eric; Kelly, John M; (2015) Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging. Antimicrobial agents and chemotherapy, 59 (8). pp. 4653-4661. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.00520-15

Francisco, Amanda Fortes; Lewis, Michael D; Jayawardhana, Shiromani; Taylor, Martin C; Chatelain, Eric; Kelly, John M; (2015) Reply to "Drug Susceptibility of Genetically Engineered Trypanosoma cruzi Strains and Sterile Cure in Animal Models as a Criterion for Potential Clinical Efficacy of Anti-T. cruzi Drugs". Antimicrobial agents and chemotherapy, 59 (12). 7925-. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.02022-15

Sola, Irene; Castellà, Sílvia; Viayna, Elisabet; Galdeano, Carles; Taylor, Martin C; Gbedema, Stephen Y; Pérez, Belén; Clos, M Victòria; Jones, Deuan C; Fairlamb, Alan H; +3 more... Wright, Colin W; Kelly, John M; Muñoz-Torrero, Diego; (2015) Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity. Bioorganic & medicinal chemistry, 23 (16). pp. 5156-5167. ISSN 0968-0896 DOI: https://doi.org/10.1016/j.bmc.2015.01.031 Full text not available from this repository.

Taylor, Martin C; Lewis, Michael D; Fortes Francisco, Amanda; Wilkinson, Shane R; Kelly, John M; (2015) The Trypanosoma cruzi vitamin C dependent peroxidase confers protection against oxidative stress but is not a determinant of virulence. PLoS neglected tropical diseases, 9 (4). e0003707-. ISSN 1935-2727 DOI: https://doi.org/10.1371/journal.pntd.0003707

Campos, Mônica CO; Leon, Leonor L; Taylor, Martin C; Kelly, John M; (2014) Benznidazole-resistance in Trypanosoma cruzi: evidence that distinct mechanisms can act in concert. Molecular and biochemical parasitology, 193 (1). pp. 17-19. ISSN 0166-6851 DOI: https://doi.org/10.1016/j.molbiopara.2014.01.002

Lewis, Michael D; Fortes Francisco, Amanda; Taylor, Martin C; Burrell-Saward, Hollie; McLatchie, Alex P; Miles, Michael A; Kelly, John M; (2014) Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue-specific parasite dynamics and heart disease in the absence of locally persistent infection. Cellular microbiology, 16 (9). pp. 1285-1300. ISSN 1462-5814 DOI: https://doi.org/10.1111/cmi.12297

Lewis, Michael D; Francisco, Amanda Fortes; Taylor, Martin C; Kelly, John M; (2014) A new experimental model for assessing drug efficacy against Trypanosoma cruzi infection based on highly sensitive in vivo imaging. Journal of biomolecular screening, 20 (1). pp. 36-43. ISSN 1087-0571 DOI: https://doi.org/10.1177/1087057114552623

Sola, Irene; Artigas, Albert; Taylor, Martin C; Gbedema, Stephen Y; Pérez, Belén; Clos, M Victòria; Wright, Colin W; Kelly, John M; Muñoz-Torrero, Diego; (2014) Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines. Bioorganic & medicinal chemistry letters, 24 (23). pp. 5435-5438. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2014.10.025 Full text not available from this repository.

Taylor, Martin C; Kelly, John M; (2014) Optimizing bioluminescence imaging to study protozoan parasite infections. Trends in parasitology, 30 (4). pp. 161-162. ISSN 1471-4922 DOI: https://doi.org/10.1016/j.pt.2014.01.006 Full text not available from this repository.

Alsford, Sam; Kelly, John M; Baker, Nicola; Horn, David; (2013) Genetic dissection of drug resistance in trypanosomes. Parasitology, 140 (12). pp. 1478-1491. ISSN 0031-1820 DOI: https://doi.org/10.1017/S003118201300022X

Koperniku, Ana; Papanastasiou, Ioannis; Foscolos, George B; Tsotinis, Andrew; Taylor, Martin C; Kelly, John M; (2013) Synthesis and trypanocidal action of new adamantane substituted imidazolines. MedChemComm, 4 (5). p. 856. ISSN 2040-2503 DOI: https://doi.org/10.1039/c3md00081h Full text not available from this repository.

McLatchie, Alex P; Burrell-Saward, Hollie; Myburgh, Elmarie; Lewis, Michael D; Ward, Theresa H; Mottram, Jeremy C; Croft, Simon L; Kelly, John M; Taylor, Martin C; (2013) Highly sensitive in vivo imaging of Trypanosoma brucei expressing "red-shifted" luciferase. PLoS neglected tropical diseases, 7 (11). e2571-. ISSN 1935-2727 DOI: https://doi.org/10.1371/journal.pntd.0002571

Taylor, Martin C; McLatchie, Alex P; Kelly, John M; (2013) Evidence that transport of iron from the lysosome to the cytosol in African trypanosomes is mediated by a mucolipin orthologue. Molecular microbiology, 89 (3). pp. 420-432. ISSN 0950-382X DOI: https://doi.org/10.1111/mmi.12285

Tsatsaroni, Alexandra; Zoidis, Grigoris; Zoumpoulakis, Panagiotis; Tsotinis, Andrew; Taylor, Martin C; Kelly, John M; Fytas, George; (2013) An E/Z conformational behaviour study on the trypanocidal action of lipophilic spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acids. Tetrahedron letters, 54 (25). pp. 3238-3240. ISSN 0040-4039 DOI: https://doi.org/10.1016/j.tetlet.2013.03.128

Echeverry, Maria C; Bot, Christopher; Obado, Samson O; Taylor, Martin C; Kelly, John M; (2012) Centromere-associated repeat arrays on Trypanosoma brucei chromosomes are much more extensive than predicted. BMC genomics, 13 (1). 29-. ISSN 1471-2164 DOI: https://doi.org/10.1186/1471-2164-13-29

Kelly, John M; Taylor, Martin C; Horn, David; Loza, Einars; Kalvinsh, Ivars; Björkling, Fredrik; (2012) Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei. Bioorganic & medicinal chemistry letters, 22 (5). pp. 1886-1890. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2012.01.072

Mejia, Ana Maria; Hall, Belinda S; Taylor, Martin C; Gómez-Palacio, Andrés; Wilkinson, Shane R; Triana-Chávez, Omar; Kelly, John M; (2012) Benznidazole-resistance in Trypanosoma cruzi is a readily acquired trait that can arise independently in a single population. The Journal of infectious diseases, 206 (2). pp. 220-228. ISSN 0022-1899 DOI: https://doi.org/10.1093/infdis/jis331

Torres, Eva; Duque, María D; López-Querol, Marta; Taylor, Martin C; Naesens, Lieve; Ma, Chunlong; Pinto, Lawrence H; Sureda, Francesc X; Kelly, John M; Vázquez, Santiago; (2012) Synthesis of benzopolycyclic cage amines: NMDA receptor antagonist, trypanocidal and antiviral activities. Bioorganic & medicinal chemistry, 20 (2). pp. 942-948. ISSN 0968-0896 DOI: https://doi.org/10.1016/j.bmc.2011.11.050 Full text not available from this repository.

Defaux, Julien; Sala, Marta; Formosa, Xavier; Galdeano, Carles; Taylor, Martin C; Alobaid, Waleed AA; Kelly, John M; Wright, Colin W; Camps, Pelayo; Muñoz-Torrero, Diego; (2011) Huprines as a new family of dual acting trypanocidal-antiplasmodial agents. Bioorganic & medicinal chemistry, 19 (5). pp. 1702-1707. ISSN 0968-0896 DOI: https://doi.org/10.1016/j.bmc.2011.01.028

Fytas, Christos; Zoidis, Grigoris; Tzoutzas, Nikolaos; Taylor, Martin C; Fytas, George; Kelly, John M; (2011) Novel lipophilic acetohydroxamic acid derivatives based on conformationally constrained spiro carbocyclic 2,6-diketopiperazine scaffolds with potent trypanocidal activity. Journal of medicinal chemistry, 54 (14). pp. 5250-5254. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm200217m

Obado, Samson O; Bot, Christopher; Echeverry, Maria C; Bayona, Julio C; Alvarez, Vanina E; Taylor, Martin C; Kelly, John M; (2011) Centromere-associated topoisomerase activity in bloodstream form Trypanosoma brucei. Nucleic acids research, 39 (3). pp. 1023-1033. ISSN 0305-1048 DOI: https://doi.org/10.1093/nar/gkq839

Taylor, Martin C; Huang, Huan; Kelly, John M; (2011) Genetic techniques in Trypanosoma cruzi. Advances in parasitology, 75. pp. 231-250. ISSN 0065-308X DOI: https://doi.org/10.1016/B978-0-12-385863-4.00011-3 Full text not available from this repository.

Wilkinson, Shane R; Bot, Christopher; Kelly, John M; Hall, Belinda S; (2011) Trypanocidal activity of nitroaromatic prodrugs: current treatments and future perspectives. Current topics in medicinal chemistry, 11 (16). pp. 2072-2084. ISSN 1568-0266 DOI: https://doi.org/10.2174/156802611796575894 Full text not available from this repository.

Duque, María D; Camps, Pelayo; Torres, Eva; Valverde, Elena; Sureda, Francesc X; López-Querol, Marta; Camins, Antoni; Prathalingam, S Radhika; Kelly, John M; Vázquez, Santiago; (2010) New oxapolycyclic cage amines with NMDA receptor antagonist and trypanocidal activities. Bioorganic & medicinal chemistry, 18 (1). pp. 46-57. ISSN 0968-0896 DOI: https://doi.org/10.1016/j.bmc.2009.11.017 Full text not available from this repository.

Patel, Shreenal; Hussain, Syeed; Harris, Richard; Sardiwal, Sunita; Kelly, John M; Wilkinson, Shane R; Driscoll, Paul C; Djordjevic, Snezana; (2010) Structural insights into the catalytic mechanism of Trypanosoma cruzi GPXI (glutathione peroxidase-like enzyme I). The Biochemical journal, 425 (3). pp. 513-522. ISSN 0264-6021 DOI: https://doi.org/10.1042/BJ20091167 Full text not available from this repository.

Taylor, MC; Kelly, JM; (2010) Iron metabolism in trypanosomatids, and its crucial role in infection. Parasitology, 137 (6). pp. 899-917. ISSN 0031-1820 DOI: https://doi.org/10.1017/S0031182009991880

Zoidis, Grigoris; Kolocouris, Nicolas; Kelly, John M; Prathalingam, S Radhika; Naesens, Lieve; De Clercq, Erik; (2010) Design and synthesis of bioactive adamantanaminoalcohols and adamantanamines. European journal of medicinal chemistry, 45 (11). pp. 5022-5030. ISSN 0223-5234 DOI: https://doi.org/10.1016/j.ejmech.2010.08.009 Full text not available from this repository.

Duque, María D; Camps, Pelayo; Profire, Lenuta; Montaner, Silvia; Vázquez, Santiago; Sureda, Francesc X; Mallol, Jordi; López-Querol, Marta; Naesens, Lieve; De Clercq, Erik; +2 more... Prathalingam, S Radhika; Kelly, John M; (2009) Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines. Bioorganic & medicinal chemistry, 17 (8). pp. 3198-3206. ISSN 0968-0896 DOI: https://doi.org/10.1016/j.bmc.2009.02.007 Full text not available from this repository.

Papanastasiou, Ioannis; Tsotinis, Andrew; Zoidis, Grigoris; Kolocouris, Nicolas; Prathalingam, S Radhika; Kelly, John M; (2009) Design and synthesis of Trypanosoma brucei active 1-alkyloxy and 1-benzyloxyadamantano 2-guanylhydrazones. ChemMedChem, 4 (7). pp. 1059-1062. ISSN 1860-7179 DOI: https://doi.org/10.1002/cmdc.200900019 Full text not available from this repository.

Wilkinson, Shane R; Kelly, John M; (2009) Trypanocidal drugs: mechanisms, resistance and new targets. Expert reviews in molecular medicine, 11. e31-. ISSN 1462-3994 DOI: https://doi.org/10.1017/S1462399409001252 Full text not available from this repository.

Camps, Pelayo; Duque, María D; Vázquez, Santiago; Naesens, Lieve; De Clercq, Erik; Sureda, Francesc X; López-Querol, Marta; Camins, Antoni; Pallàs, Mercè; Prathalingam, S Radhika; +4 more... Kelly, John M; Romero, Vanessa; Ivorra, Dolores; Cortés, Diego; (2008) Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs. Bioorganic & medicinal chemistry, 16 (23). pp. 9925-9936. ISSN 0968-0896 DOI: https://doi.org/10.1016/j.bmc.2008.10.028 Full text not available from this repository.

Papanastasiou, Ioannis; Tsotinis, Andrew; Foscolos, George B; Prathalingam, S Radhika; Kelly, John M; (2008) Synthesis of conformationally constrained adamantane imidazolines with trypanocidal activity. Journal of heterocyclic chemistry, 45 (5). pp. 1401-1406. ISSN 0022-152X DOI: https://doi.org/10.1002/jhet.5570450524 Full text not available from this repository.

Papanastasiou, Ioannis; Tsotinis, Andrew; Kolocouris, Nicolas; Prathalingam, S Radhika; Kelly, John M; (2008) Design, synthesis, and trypanocidal activity of new aminoadamantane derivatives. Journal of medicinal chemistry, 51 (5). pp. 1496-1500. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm7014292 Full text not available from this repository.

Piacenza, Lucía; Peluffo, Gonzalo; Alvarez, María Noel; Kelly, John M; Wilkinson, Shane R; Radi, Rafael; (2008) Peroxiredoxins play a major role in protecting Trypanosoma cruzi against macrophage- and endogenously-derived peroxynitrite. The Biochemical journal, 410 (2). pp. 359-368. ISSN 0264-6021 DOI: https://doi.org/10.1042/BJ20071138 Full text not available from this repository.

Taylor, Martin C; Kaur, Harparkash; Blessington, Bernard; Kelly, John M; Wilkinson, Shane R; (2008) Validation of spermidine synthase as a drug target in African trypanosomes. The Biochemical journal, 409 (2). pp. 563-569. ISSN 0264-6021 DOI: https://doi.org/10.1042/BJ20071185 Full text not available from this repository.

Wilkinson, Shane R; Taylor, Martin C; Horn, David; Kelly, John M; Cheeseman, Ian; (2008) A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes. Proceedings of the National Academy of Sciences of the United States of America, 105 (13). pp. 5022-5027. ISSN 0027-8424 DOI: https://doi.org/10.1073/pnas.0711014105 Full text not available from this repository.

Zoidis, Grigoris; Tsotinis, Andrew; Kolocouris, Nicolas; Kelly, John M; Prathalingam, S Radhika; Naesens, Lieve; De Clercq, Erik; (2008) Design and synthesis of bioactive 1,2-annulated adamantane derivatives. Organic & biomolecular chemistry, 6 (17). pp. 3177-3185. ISSN 1477-0520 DOI: https://doi.org/10.1039/b804907f Full text not available from this repository.

Gluenz, Eva; Taylor, Martin C; Kelly, John M; (2007) The Trypanosoma cruzi metacyclic-specific protein Met-III associates with the nucleolus and contains independent amino and carboxyl terminal targeting elements. International journal for parasitology, 37 (6). pp. 617-625. ISSN 0020-7519 DOI: https://doi.org/10.1016/j.ijpara.2006.11.016

Kolocouris, Nicolas; Zoidis, Grigoris; Foscolos, George B; Fytas, George; Prathalingham, S Radhika; Kelly, John M; Naesens, Lieve; De Clercq, Erik; (2007) Design and synthesis of bioactive adamantane spiro heterocycles. Bioorganic & medicinal chemistry letters, 17 (15). pp. 4358-4362. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2007.04.108 Full text not available from this repository.

Logan, Flora J; Taylor, Martin C; Wilkinson, Shane R; Kaur, Harparkash; Kelly, John M; (2007) The terminal step in vitamin C biosynthesis in Trypanosoma cruzi is mediated by a FMN-dependent galactonolactone oxidase. The Biochemical journal, 407 (3). pp. 419-426. ISSN 0264-6021 DOI: https://doi.org/10.1042/BJ20070766 Full text not available from this repository.

Obado, Samson O; Bot, Christopher; Nilsson, Daniel; Andersson, Bjorn; Kelly, John M; (2007) Repetitive DNA is associated with centromeric domains in Trypanosoma brucei but not Trypanosoma cruzi. Genome biology, 8 (3). R37-. ISSN 1465-6906 DOI: https://doi.org/10.1186/gb-2007-8-3-r37

Piacenza, Lucía; Irigoín, Florencia; Alvarez, María Noel; Peluffo, Gonzalo; Taylor, Martin C; Kelly, John M; Wilkinson, Shane R; Radi, Rafael; (2007) Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpression. The Biochemical journal, 403 (2). pp. 323-334. ISSN 0264-6021 DOI: https://doi.org/10.1042/BJ20061281 Full text not available from this repository.

Prathalingham, S Radhika; Wilkinson, Shane R; Horn, David; Kelly, John M; (2007) Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole. Antimicrobial agents and chemotherapy, 51 (2). pp. 755-758. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.01360-06 Full text not available from this repository.

Prathalingham, SR; Wilkinson, SR; Horn, D; Kelly, JM; (2007) Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole. Antimicrobial agents and chemotherapy, 51 (2). pp. 755-758. ISSN 0066-4804 DOI: https://doi.org/10.1128/aac.01360-06 Full text not available from this repository.

Renauld, H; Kelly, JM; Horn, D; (2007) Chromosome structure and dynamics. In: Barry, D; Mottram, J; McCulloch, R; Acosta-Serrano, A; Renauld, H, (eds.) Trypanosomes - After the Genome. Horizon Scientific Press, Norwich, UK., pp. 91-132. https://researchonline.lshtm.ac.uk/id/eprint/11566 Full text not available from this repository.

Kelly, John M; McRobert, Louisa; Baker, David A; (2006) Evidence on the chromosomal location of centromeric DNA in Plasmodium falciparum from etoposide-mediated topoisomerase-II cleavage. Proceedings of the National Academy of Sciences of the United States of America, 103 (17). pp. 6706-6711. ISSN 0027-8424 DOI: https://doi.org/10.1073/pnas.0510363103 Full text not available from this repository.

MacRae, James I; Obado, Samson O; Turnock, Daniel C; Roper, Janine R; Kierans, Martin; Kelly, John M; Ferguson, Michael AJ; (2006) The suppression of galactose metabolism in Trypanosoma cruzi epimastigotes causes changes in cell surface molecular architecture and cell morphology. Molecular and biochemical parasitology, 147 (1). pp. 126-136. ISSN 0166-6851 DOI: https://doi.org/10.1016/j.molbiopara.2006.02.011 Full text not available from this repository.

Taylor, Martin C; Kelly, John M; (2006) pTcINDEX: a stable tetracycline-regulated expression vector for Trypanosoma cruzi. BMC biotechnology, 6 (1). 32-. ISSN 1472-6750 DOI: https://doi.org/10.1186/1472-6750-6-32

Wilkinson, Shane R; Prathalingam, S Radhika; Taylor, Martin C; Ahmed, Aiyaz; Horn, David; Kelly, John M; (2006) Functional characterisation of the iron superoxide dismutase gene repertoire in Trypanosoma brucei. Free radical biology & medicine, 40 (2). pp. 198-209. ISSN 0891-5849 DOI: https://doi.org/10.1016/j.freeradbiomed.2005.06.022 Full text not available from this repository.

Gluenz, E; (2005) Developmentally regulated genes in Trypansoma Cruzi. PhD thesis, London School of Hygiene and Tropical Medicine. DOI: https://doi.org/10.17037/PUBS.04654693

Kelly, JM; Taylor, MC; Wilkinson, SR; (2005) Trypanosoma cruzi. In: Fuchs, J; Podda, M; Goethe, JW, (eds.) Encyclopedia of Diagnostic Genomics and Proteomics. Marcel Dekker, Inc., New York, USA, pp. 1297-1301. https://researchonline.lshtm.ac.uk/id/eprint/15644 Full text not available from this repository.

Obado, Samson O; Taylor, Martin C; Wilkinson, Shane R; Bromley, Elizabeth V; Kelly, John M; (2005) Functional mapping of a trypanosome centromere by chromosome fragmentation identifies a 16-kb GC-rich transcriptional "strand-switch" domain as a major feature. Genome research, 15 (1). pp. 36-43. ISSN 1088-9051 DOI: https://doi.org/10.1101/gr.2895105

Wilkinson, Shane R; Prathalingam, S Radhika; Taylor, Martin C; Horn, David; Kelly, John M; (2005) Vitamin C biosynthesis in trypanosomes: a role for the glycosome. Proceedings of the National Academy of Sciences of the United States of America, 102 (33). pp. 11645-11650. ISSN 0027-8424 DOI: https://doi.org/10.1073/pnas.0504251102 Full text not available from this repository.

Baker, David A; Kelly, John M; (2004) Structure, function and evolution of microbial adenylyl and guanylyl cyclases. Molecular microbiology, 52 (5). pp. 1229-1242. ISSN 0950-382X DOI: https://doi.org/10.1111/j.1365-2958.2004.04067.x Full text not available from this repository.

Baker, David A; Kelly, John M; (2004) Purine nucleotide cyclases in the malaria parasite. Trends in parasitology, 20 (5). pp. 227-232. ISSN 1471-4922 DOI: https://doi.org/10.1016/j.pt.2004.02.007 Full text not available from this repository.

Bromley, Elizabeth V; Taylor, Martin C; Wilkinson, Shane R; Kelly, John M; (2004) The amino terminal domain of a novel WD repeat protein from Trypanosoma cruzi contains a non-canonical mitochondrial targeting signal. International journal for parasitology, 34 (1). pp. 63-71. ISSN 0020-7519 DOI: https://doi.org/10.1016/j.ijpara.2003.09.004 Full text not available from this repository.

Kelly, JM; Obado, SO; Taylor, MC; (2004) Functional mapping of an American trypanosome centromere [Abstract]. Springer Verlag. https://researchonline.lshtm.ac.uk/id/eprint/19454 Full text not available from this repository.

Kelly, JM; (2003) Molecular Mechanisms in the Pathogenesis of Chagas? Disease. Landes Bioscience, Georgetown, Texas, USA. https://researchonline.lshtm.ac.uk/id/eprint/15543 Full text not available from this repository.

Muhia, David K; Swales, Claire A; Eckstein-Ludwig, Ursula; Saran, Shweta; Polley, Spencer D; Kelly, John M; Schaap, Pauline; Krishna, Sanjeev; Baker, David A; (2003) Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparum. The Journal of biological chemistry, 278 (24). pp. 22014-22022. ISSN 0021-9258 DOI: https://doi.org/10.1074/jbc.M301639200 Full text not available from this repository.

Wilkinson, SR; Kelly, JM; (2003) How does Trypanosoma cruzi survive the toxic effects of reactive oxygen species? In: Kelly, JM, (ed.) Molecular Mechanisms in the Pathogenesis of Chagas? Disease. Landes Bioscience, Georgetown, Texas, USA, pp. 56-71. https://researchonline.lshtm.ac.uk/id/eprint/15542 Full text not available from this repository.

Wilkinson, Shane R; Horn, David; Prathalingam, S Radhika; Kelly, John M; (2003) RNA interference identifies two hydroperoxide metabolizing enzymes that are essential to the bloodstream form of the african trypanosome. The Journal of biological chemistry, 278 (34). pp. 31640-31646. ISSN 0021-9258 DOI: https://doi.org/10.1074/jbc.M303035200 Full text not available from this repository.

Wilkinson, Shane R; Kelly, John M; (2003) The role of glutathione peroxidases in trypanosomatids. Biological chemistry, 384 (4). pp. 517-525. ISSN 1431-6730 DOI: https://doi.org/10.1515/BC.2003.060 Full text not available from this repository.

Kelly, JM; Obado, S; (2002) Chromosome fragmentation as an approach to whole-genome analysis in trypanosomes. In: Wren, BW; Dorrell, N, (eds.) Functional Microbial Genomics. Academic Press Inc, San Diego, pp. 397-406. https://researchonline.lshtm.ac.uk/id/eprint/16484 Full text not available from this repository.

Ruben, L; Kelly, JM; Chakrabarti, D; (2002) Intracellular signalling. In: Koumuniecki, R; Nilsen, T; Marr, JJ, (eds.) Molecular Medical Parasitology. Academic Press, London, pp. 241-276. https://researchonline.lshtm.ac.uk/id/eprint/15541 Full text not available from this repository.

Taylor, MC; Kelly, JM; (2002) Functional dissection of the Trypanosoma cruzi genome: New approaches in a new era. In: Tyler, K; Miles, MA, (eds.) American Trypanosomiasis. Kluwer Academic Publishers, London, pp. 57-68. https://researchonline.lshtm.ac.uk/id/eprint/15544 Full text not available from this repository.

Wilkinson, Shane R; Meyer, David J; Taylor, Martin C; Bromley, Elizabeth V; Miles, Michael A; Kelly, John M; (2002) The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin. The Journal of biological chemistry, 277 (19). pp. 17062-17071. ISSN 0021-9258 DOI: https://doi.org/10.1074/jbc.M111126200 Full text not available from this repository.

Wilkinson, Shane R; Obado, Samson O; Mauricio, Isabel L; Kelly, John M; (2002) Trypanosoma cruzi expresses a plant-like ascorbate-dependent hemoperoxidase localized to the endoplasmic reticulum. Proceedings of the National Academy of Sciences of the United States of America, 99 (21). pp. 13453-13458. ISSN 0027-8424 DOI: https://doi.org/10.1073/pnas.202422899 Full text not available from this repository.

Wilkinson, Shane R; Taylor, Martin C; Touitha, Said; Mauricio, Isabel L; Meyer, David J; Kelly, John M; (2002) TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulum. The Biochemical journal, 364 (Pt 3). pp. 787-794. ISSN 0264-6021 DOI: https://doi.org/10.1042/BJ20020038 Full text not available from this repository.

Allen, CL; Kelly, JM; (2001) Trypanosoma cruzi: mucin pseudogenes organized in a tandem array. Experimental parasitology, 97 (3). pp. 173-177. ISSN 0014-4894 DOI: https://doi.org/10.1006/expr.2001.4600 Full text not available from this repository.

Kelly, JM; Quack, G; Miles, MM; (2001) In vitro and in vivo activities of aminoadamantane and aminoalkylcyclohexane derivatives against Trypanosoma brucei. Antimicrobial agents and chemotherapy, 45 (5). pp. 1360-1366. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.45.5.1360-1366.2001 Full text not available from this repository.

Muhia, DK; Swales, CA; Deng, W; Kelly, JM; Baker, DA; (2001) The gametocyte-activating factor xanthurenic acid stimulates an increase in membrane-associated guanylyl cyclase activity in the human malaria parasite Plasmodium falciparum. Molecular microbiology, 42 (2). pp. 553-560. ISSN 0950-382X DOI: https://doi.org/10.1046/j.1365-2958.2001.02665.x Full text not available from this repository.