Items where Author is "Delves, Michael J"
Number of items: 68.
2024
Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4. (2024)
Ashton, Trent D; Calic, Petar PS; Dans, Madeline G; Kang Ooi, Zi; Zhou, Qingmiao; Loi, Katie; Jarman, Kate E; Palandri, Josephine; Qiu, Deyun; Lehane, Adele M; Maity, Bikash; De, Nirupam; Famodimu, Mufuliat T; Delves, Michael J; Mao, Emma Y; Gancheva, Maria R; Wilson, Danny W; Chowdury, Mrittika; de Koning-Ward, Tania F; Baud, Delphine; Brand, Stephen; Jackson, Paul F; Cowman, Alan F; Sleebs, Brad E
Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b. (2024)
Awalt, Jon Kyle; Su, Wenyin; Nguyen, William; Loi, Katie; Jarman, Kate E; Penington, Jocelyn S; Ramesh, Saishyam; Fairhurst, Kate J; Yeo, Tomas; Park, Heekuk; Uhlemann, Anne-Catrin; Chandra Maity, Bikash; De, Nirupam; Mukherjee, Partha; Chakraborty, Arnish; Churchyard, Alisje; Famodimu, Mufuliat T; Delves, Michael J; Baum, Jake; Mittal, Nimisha; Winzeler, Elizabeth A; Papenfuss, Anthony T; Chowdury, Mrittika; de Koning-Ward, Tania F; Maier, Alexander G; van Dooren, Giel G; Baud, Delphine; Brand, Stephen; Fidock, David A; Jackson, Paul F; Cowman, Alan F; Dans, Madeline G; Sleebs, Brad E
Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1. (2024)
Dans, Madeline G; Boulet, Coralie; Watson, Gabrielle M; Nguyen, William; Dziekan, Jerzy M; Evelyn, Cindy; Reaksudsan, Kitsanapong; Mehra, Somya; Razook, Zahra; Geoghegan, Niall D; Mlodzianoski, Michael J; Goodman, Christopher Dean; Ling, Dawson B; Jonsdottir, Thorey K; Tong, Joshua; Famodimu, Mufuliat Toyin; Kristan, Mojca; Pollard, Harry; Stewart, Lindsay B; Brandner-Garrod, Luke; Sutherland, Colin J; Delves, Michael J; McFadden, Geoffrey I; Barry, Alyssa E; Crabb, Brendan S; de Koning-Ward, Tania F; Rogers, Kelly L; Cowman, Alan F; Tham, Wai-Hong; Sleebs, Brad E; Gilson, Paul R
A Pan Plasmodium lateral flow recombinase polymerase amplification assay for monitoring malaria parasites in vectors and human populations. (2024)
Higgins, Matthew; Kristan, Mojca; Collins, Emma L; Messenger, Louisa A; Dombrowski, Jamille G; Vanheer, Leen N; Nolder, Debbie; Drakeley, Christopher J; Stone, William; Mahamar, Almahamoudou; Bousema, Teun; Delves, Michael; Bandibabone, Janvier; N'Do, Sévérin; Bantuzeko, Chimanuka; Zawadi, Bertin; Walker, Thomas; Sutherland, Colin J; Marinho, Claudio RF; Cameron, Mary M; Clark, Taane G; Campino, Susana
Tambjamines as Fast-Acting Multistage Antimalarials. (2024)
Kumar, Amrendra; Li, Yuexin; Dodean, Rozalia A; Roth, Alison; Caridha, Diana; Madejczyk, Michael S; Jin, Xiannu; Dennis, William E; Lee, Patricia J; Pybus, Brandon S; Martin, Monica; Pannone, Kristina; Dinh, Hieu T; Blount, Cameron; Chetree, Ravi; DeLuca, Jesse; Evans, Martin; Nadeau, Robert; Vuong, Chau; Leed, Susan; Black, Chad; Sousa, Jason; Nolan, Christina; Ceja, Frida G; Rasmussen, Stephanie A; Tumwebaze, Patrick K; Rosenthal, Philip J; Cooper, Roland A; Rottmann, Matthias; Orjuela-Sanchez, Pamela; Meister, Stephan; Winzeler, Elizabeth A; Delves, Michael J; Matthews, Holly; Baum, Jake; Kirby, Robert W; Burrows, Jeremy N; Duffy, James; Peyton, David H; Reynolds, Kevin A; Kelly, Jane X; Kancharla, Papireddy
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Optimisation-based modelling for explainable lead discovery in malaria. (2024)
Li, Yutong; Cardoso-Silva, Jonathan; Kelly, John M; Delves, Michael J; Furnham, Nicholas; Papageorgiou, Lazaros G; Tsoka, Sophia
A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo. (2024)
Xie, Stanley C; Tai, Chia-Wei; Morton, Craig J; Ma, Liting; Huang, Shih-Chung; Wittlin, Sergio; Du, Yawei; Hu, Yongbo; Dogovski, Con; Salimimarand, Mina; Griffin, Robert; England, Dylan; de la Cruz, Elisa; Deni, Ioanna; Yeo, Tomas; Burkhard, Anna Y; Striepen, Josefine; Schindler, Kyra A; Crespo, Benigno; Gamo, Francisco J; Khandokar, Yogesh; Hutton, Craig A; Rabie, Tayla; Birkholtz, Lyn-Marié; Famodimu, Mufuliat T; Delves, Michael J; Bolsher, Judith; Koolen, Karin MJ; van der Laak, Rianne; Aguiar, Anna CC; Pereira, Dhelio B; Guido, Rafael VC; Creek, Darren J; Fidock, David A; Dick, Lawrence R; Brand, Stephen L; Gould, Alexandra E; Langston, Steven; Griffin, Michael DW; Tilley, Leann
2023
A Pyridyl-Furan Series Developed from the Open Global Health Library Block Red Blood Cell Invasion and Protein Trafficking in Plasmodium falciparum through Potential Inhibition of the Parasite's PI4KIIIB Enzyme. (2023)
Ling, Dawson B; Nguyen, William; Looker, Oliver; Razook, Zahra; McCann, Kirsty; Barry, Alyssa E; Scheurer, Christian; Wittlin, Sergio; Famodimu, Mufuliat Toyin; Delves, Michael J; Bullen, Hayley E; Crabb, Brendan S; Sleebs, Brad E; Gilson, Paul R
Bis-6-amidino-benzothiazole Derivative that Cures Experimental Stage 1 African Trypanosomiasis with a Single Dose. (2023)
Racané, Livio; Ptiček, Lucija; Kostrun, Sanja; Raić-Malić, Silvana; Taylor, Martin Craig; Delves, Michael; Alsford, Sam; Olmo, Francisco; Francisco, Amanda Fortes; Kelly, John M
Exploring energy metabolism in male and female Plasmodium falciparum gametocytes. (2023)
Sparkes, PC
A novel class of sulphonamides potently block malaria transmission by targeting a Plasmodium vacuole membrane protein. (2023)
Yahiya, Sabrina; Saunders, Charlie N; Hassan, Sarah; Straschil, Ursula; Fischer, Oliver J; Rueda-Zubiaurre, Ainoa; Haase, Silvia; Vizcay-Barrena, Gema; Famodimu, Mufuliat Toyin; Jordan, Sarah; Delves, Michael J; Tate, Edward W; Barnard, Anna; Fuchter, Matthew J; Baum, Jake
2021
The Novel bis-1,2,4-Triazine MIPS-0004373 Demonstrates Rapid and Potent Activity against All Blood Stages of the Malaria Parasite. (2021)
Ellis, Katherine M; Lucantoni, Leonardo; Chavchich, Marina; Abraham, Matthew; De Paoli, Amanda; Luth, Madeline R; Zeeman, Anne-Marie; Delves, Michael J; Terán, Fernando Sánchez-Román; Straschil, Ursula; Baum, Jake; Kocken, Clemens HM; Ralph, Stuart A; Winzeler, Elizabeth A; Avery, Vicky M; Edstein, Michael D; Baell, Jonathan B; Creek, Darren J
The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957. (2021)
Miguel-Blanco, Celia; Murithi, James M; Benavente, Ernest Diez; Angrisano, Fiona; Sala, Katarzyna A; van Schalkwyk, Donelly A; Vanaerschot, Manu; Schwach, Frank; Fuchter, Matthew J; Billker, Oliver; Sutherland, Colin J; Campino, Susana G; Clark, Taane G; Blagborough, Andrew M; Fidock, David A; Herreros, Esperanza; Gamo, Francisco Javier; Baum, Jake; Delves, Michael J
Transmission of Artemisinin-Resistant Malaria Parasites to Mosquitoes under Antimalarial Drug Pressure. (2021)
Witmer, Kathrin; Dahalan, Farah A; Delves, Michael J; Yahiya, Sabrina; Watson, Oliver J; Straschil, Ursula; Chiwcharoen, Darunee; Sornboon, Boodtee; Pukrittayakamee, Sasithon; Pearson, Richard D; Howick, Virginia M; Lawniczak, Mara KN; White, Nicholas J; Dondorp, Arjen M; Okell, Lucy C; Chotivanich, Kesinee; Ruecker, Andrea; Baum, Jake
2020
Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity. (2020)
Vanaerschot, Manu; Murithi, James M; Pasaje, Charisse Flerida A; Ghidelli-Disse, Sonja; Dwomoh, Louis; Bird, Megan; Spottiswoode, Natasha; Mittal, Nimisha; Arendse, Lauren B; Owen, Edward S; Wicht, Kathryn J; Siciliano, Giulia; Bösche, Markus; Yeo, Tomas; Kumar, TR Santha; Mok, Sachel; Carpenter, Emma F; Giddins, Marla J; Sanz, Olalla; Ottilie, Sabine; Alano, Pietro; Chibale, Kelly; Llinás, Manuel; Uhlemann, Anne-Catrin; Delves, Michael; Tobin, Andrew B; Doerig, Christian; Winzeler, Elizabeth A; Lee, Marcus CS; Niles, Jacquin C; Fidock, David A
2019
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis. (2019)
Baragaña, Beatriz; Forte, Barbara; Choi, Ryan; Nakazawa Hewitt, Stephen; Bueren-Calabuig, Juan A; Pisco, João Pedro; Peet, Caroline; Dranow, David M; Robinson, David A; Jansen, Chimed; Norcross, Neil R; Vinayak, Sumiti; Anderson, Mark; Brooks, Carrie F; Cooper, Caitlin A; Damerow, Sebastian; Delves, Michael; Dowers, Karen; Duffy, James; Edwards, Thomas E; Hallyburton, Irene; Horst, Benjamin G; Hulverson, Matthew A; Ferguson, Liam; Jiménez-Díaz, María Belén; Jumani, Rajiv S; Lorimer, Donald D; Love, Melissa S; Maher, Steven; Matthews, Holly; McNamara, Case W; Miller, Peter; O'Neill, Sandra; Ojo, Kayode K; Osuna-Cabello, Maria; Pinto, Erika; Post, John; Riley, Jennifer; Rottmann, Matthias; Sanz, Laura M; Scullion, Paul; Sharma, Arvind; Shepherd, Sharon M; Shishikura, Yoko; Simeons, Frederick RC; Stebbins, Erin E; Stojanovski, Laste; Straschil, Ursula; Tamaki, Fabio K; Tamjar, Jevgenia; Torrie, Leah S; Vantaux, Amélie; Witkowski, Benoît; Wittlin, Sergio; Yogavel, Manickam; Zuccotto, Fabio; Angulo-Barturen, Iñigo; Sinden, Robert; Baum, Jake; Gamo, Francisco-Javier; Mäser, Pascal; Kyle, Dennis E; Winzeler, Elizabeth A; Myler, Peter J; Wyatt, Paul G; Floyd, David; Matthews, David; Sharma, Amit; Striepen, Boris; Huston, Christopher D; Gray, David W; Fairlamb, Alan H; Pisliakov, Andrei V; Walpole, Chris; Read, Kevin D; Van Voorhis, Wesley C; Gilbert, Ian H
Transmission-blocking Effects of Primaquine and Methylene Blue Suggest Plasmodium falciparum Gametocyte Sterilization Rather Than Effects on Sex Ratio. (2019)
Bradley, John; Soumaré, Harouna M; Mahamar, Almahamoudou; Diawara, Halimatou; Roh, Michelle; Delves, Michael; Drakeley, Chris; Churcher, Thomas S; Dicko, Alassane; Gosling, Roly; Bousema, Teun
Screen of traditional soup broths with reported antipyretic activity towards the discovery of potential antimalarials. (2019)
Children of Eden Primary School; Straschil, Ursula; Witmer, Kathrin; Delves, Michael J; Marks, Stephen D; Baum, Jake
Fueling Open Innovation for Malaria Transmission-Blocking Drugs: Hundreds of Molecules Targeting Early Parasite Mosquito Stages. (2019)
Delves, Michael; Lafuente-Monasterio, M Jose; Upton, Leanna; Ruecker, Andrea; Leroy, Didier; Gamo, Francisco-Javier; Sinden, Robert
Substituted Aminoacetamides as Novel Leads for Malaria Treatment. (2019)
Norcross, Neil R; Wilson, Caroline; Baragaña, Beatriz; Hallyburton, Irene; Osuna-Cabello, Maria; Norval, Suzanne; Riley, Jennifer; Fletcher, Daniel; Sinden, Robert; Delves, Michael; Ruecker, Andrea; Duffy, Sandra; Meister, Stephan; Antonova-Koch, Yevgeniya; Crespo, Benigno; de Cózar, Cristina; Sanz, Laura M; Gamo, Francisco Javier; Avery, Vicky M; Frearson, Julie A; Gray, David W; Fairlamb, Alan H; Winzeler, Elizabeth A; Waterson, David; Campbell, Simon F; Willis, Paul A; Read, Kevin D; Gilbert, Ian H
Structure-Activity Relationship Studies of a Novel Class of Transmission Blocking Antimalarials Targeting Male Gametes. (2019)
Rueda-Zubiaurre, Ainoa; Yahiya, Sabrina; Fischer, Oliver J; Hu, Xiaojun; Saunders, Charlie N; Sharma, Sachi; Straschil, Ursula; Shen, Junting; Tate, Edward W; Delves, Michael J; Baum, Jake; Barnard, Anna; Fuchter, Matthew J
The antimalarial screening landscape-looking beyond the asexual blood stage. (2019)
Yahiya, Sabrina; Rueda-Zubiaurre, Ainoa; Delves, Michael J; Fuchter, Matthew J; Baum, Jake
Kinesin-8B controls basal body function and flagellum formation and is key to malaria transmission. (2019)
Zeeshan, Mohammad; Ferguson, David Jp; Abel, Steven; Burrrell, Alana; Rea, Edward; Brady, Declan; Daniel, Emilie; Delves, Michael; Vaughan, Sue; Holder, Anthony A; Le Roch, Karine G; Moores, Carolyn A; Tewari, Rita
2018
Antimalarial Transmission-Blocking Interventions: Past, Present, and Future. (2018)
Delves, MJ; Angrisano, F; Blagborough, AM
A high throughput screen for next-generation leads targeting malaria parasite transmission. (2018)
Delves, Michael J; Miguel-Blanco, Celia; Matthews, Holly; Molina, Irene; Ruecker, Andrea; Yahiya, Sabrina; Straschil, Ursula; Abraham, Matthew; León, María Luisa; Fischer, Oliver J; Rueda-Zubiaurre, Ainoa; Brandt, Jochen R; Cortés, Álvaro; Barnard, Anna; Fuchter, Matthew J; Calderón, Félix; Winzeler, Elizabeth A; Sinden, Robert E; Herreros, Esperanza; Gamo, Francisco J; Baum, Jake
Allele-Specific Isothermal Amplification Method Using Unmodified Self-Stabilizing Competitive Primers. (2018)
Malpartida-Cardenas, Kenny; Rodriguez-Manzano, Jesus; Yu, Ling-Shan; Delves, Michael J; Nguon, Chea; Chotivanich, Kesinee; Baum, Jake; Georgiou, Pantelis
Polyamidoamine Nanoparticles for the Oral Administration of Antimalarial Drugs. (2018)
Martí Coma-Cros, Elisabet; Biosca, Arnau; Marques, Joana; Carol, Laura; Urbán, Patricia; Berenguer, Diana; Riera, Maria Cristina; Delves, Michael; Sinden, Robert E; Valle-Delgado, Juan José; Spanos, Lefteris; Siden-Kiamos, Inga; Pérez, Paula; Paaijmans, Krijn; Rottmann, Matthias; Manfredi, Amedea; Ferruti, Paolo; Ranucci, Elisabetta; Fernàndez-Busquets, Xavier
An inexpensive open source 3D-printed membrane feeder for human malaria transmission studies. (2018)
Witmer, Kathrin; Sherrard-Smith, Ellie; Straschil, Ursula; Tunnicliff, Mark; Baum, Jake; Delves, Michael
2017
3-Hydroxy-N'-arylidenepropanehydrazonamides with Halo-Substituted Phenanthrene Scaffolds Cure P. berghei Infected Mice When Administered Perorally. (2017)
Leven, Michael; Knaab, Tanja C; Held, Jana; Duffy, Sandra; Meister, Stephan; Fischli, Christoph; Meitzner, Diane; Lehmann, Ursula; Lungerich, Beate; Kuna, Krystina; Stahlke, Petra; Delves, Michael J; Buchholz, Mirko; Winzeler, Elizabeth A; Avery, Vicky M; Mordmüller, Benjamin; Wittlin, Sergio; Kurz, Thomas
Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen. (2017)
Miguel-Blanco, Celia; Molina, Irene; Bardera, Ana I; Díaz, Beatriz; de Las Heras, Laura; Lozano, Sonia; González, Carolina; Rodrigues, Janneth; Delves, Michael J; Ruecker, Andrea; Colmenarejo, Gonzalo; Viera, Sara; Martínez-Martínez, María S; Fernández, Esther; Baum, Jake; Sinden, Robert E; Herreros, Esperanza
A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance. (2017)
O'Neill, Paul M; Amewu, Richard K; Charman, Susan A; Sabbani, Sunil; Gnädig, Nina F; Straimer, Judith; Fidock, David A; Shore, Emma R; Roberts, Natalie L; Wong, Michael H-L; Hong, W David; Pidathala, Chandrakala; Riley, Chris; Murphy, Ben; Aljayyoussi, Ghaith; Gamo, Francisco Javier; Sanz, Laura; Rodrigues, Janneth; Cortes, Carolina Gonzalez; Herreros, Esperanza; Angulo-Barturén, Iñigo; Jiménez-Díaz, María Belén; Bazaga, Santiago Ferrer; Martínez-Martínez, María Santos; Campo, Brice; Sharma, Raman; Ryan, Eileen; Shackleford, David M; Campbell, Simon; Smith, Dennis A; Wirjanata, Grennady; Noviyanti, Rintis; Price, Ric N; Marfurt, Jutta; Palmer, Michael J; Copple, Ian M; Mercer, Amy E; Ruecker, Andrea; Delves, Michael J; Sinden, Robert E; Siegl, Peter; Davies, Jill; Rochford, Rosemary; Kocken, Clemens HM; Zeeman, Anne-Marie; Nixon, Gemma L; Biagini, Giancarlo A; Ward, Stephen A
Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity. (2017)
Vanaerschot, Manu; Lucantoni, Leonardo; Li, Tao; Combrinck, Jill M; Ruecker, Andrea; Kumar, TR Santha; Rubiano, Kelly; Ferreira, Pedro E; Siciliano, Giulia; Gulati, Sonia; Henrich, Philipp P; Ng, Caroline L; Murithi, James M; Corey, Victoria C; Duffy, Sandra; Lieberman, Ori J; Veiga, M Isabel; Sinden, Robert E; Alano, Pietro; Delves, Michael J; Lee Sim, Kim; Winzeler, Elizabeth A; Egan, Timothy J; Hoffman, Stephen L; Avery, Vicky M; Fidock, David A
2016
Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy. (2016)
Baragaña, Beatriz; Norcross, Neil R; Wilson, Caroline; Porzelle, Achim; Hallyburton, Irene; Grimaldi, Raffaella; Osuna-Cabello, Maria; Norval, Suzanne; Riley, Jennifer; Stojanovski, Laste; Simeons, Frederick RC; Wyatt, Paul G; Delves, Michael J; Meister, Stephan; Duffy, Sandra; Avery, Vicky M; Winzeler, Elizabeth A; Sinden, Robert E; Wittlin, Sergio; Frearson, Julie A; Gray, David W; Fairlamb, Alan H; Waterson, David; Campbell, Simon F; Willis, Paul; Read, Kevin D; Gilbert, Ian H
Routine in vitro culture of P. falciparum gametocytes to evaluate novel transmission-blocking interventions. (2016)
Delves, Michael J; Straschil, Ursula; Ruecker, Andrea; Miguel-Blanco, Celia; Marques, Sara; Dufour, Alexandre C; Baum, Jake; Sinden, Robert E
Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling. (2016)
Le Bihan, Amélie; de Kanter, Ruben; Angulo-Barturen, Iñigo; Binkert, Christoph; Boss, Christoph; Brun, Reto; Brunner, Ralf; Buchmann, Stephan; Burrows, Jeremy; Dechering, Koen J; Delves, Michael; Ewerling, Sonja; Ferrer, Santiago; Fischli, Christoph; Gamo-Benito, Francisco Javier; Gnädig, Nina F; Heidmann, Bibia; Jiménez-Díaz, María Belén; Leroy, Didier; Martínez, Maria Santos; Meyer, Solange; Moehrle, Joerg J; Ng, Caroline L; Noviyanti, Rintis; Ruecker, Andrea; Sanz, Laura María; Sauerwein, Robert W; Scheurer, Christian; Schleiferboeck, Sarah; Sinden, Robert; Snyder, Christopher; Straimer, Judith; Wirjanata, Grennady; Marfurt, Jutta; Price, Ric N; Weller, Thomas; Fischli, Walter; Fidock, David A; Clozel, Martine; Wittlin, Sergio
Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery. (2016)
Marques, Joana; Valle-Delgado, Juan José; Urbán, Patricia; Baró, Elisabet; Prohens, Rafel; Mayor, Alfredo; Cisteró, Pau; Delves, Michael; Sinden, Robert E; Grandfils, Christian; de Paz, José L; García-Salcedo, José A; Fernàndez-Busquets, Xavier
Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. (2016)
Paquet, Tanya; Le Manach, Claire; Cabrera, Diego González; Younis, Yassir; Henrich, Philipp P; Abraham, Tara S; Lee, Marcus CS; Basak, Rajshekhar; Ghidelli-Disse, Sonja; Lafuente-Monasterio, María José; Bantscheff, Marcus; Ruecker, Andrea; Blagborough, Andrew M; Zakutansky, Sara E; Zeeman, Anne-Marie; White, Karen L; Shackleford, David M; Mannila, Janne; Morizzi, Julia; Scheurer, Christian; Angulo-Barturen, Iñigo; Martínez, María Santos; Ferrer, Santiago; Sanz, Laura María; Gamo, Francisco Javier; Reader, Janette; Botha, Mariette; Dechering, Koen J; Sauerwein, Robert W; Tungtaeng, Anchalee; Vanachayangkul, Pattaraporn; Lim, Chek Shik; Burrows, Jeremy; Witty, Michael J; Marsh, Kennan C; Bodenreider, Christophe; Rochford, Rosemary; Solapure, Suresh M; Jiménez-Díaz, María Belén; Wittlin, Sergio; Charman, Susan A; Donini, Cristina; Campo, Brice; Birkholtz, Lyn-Marie; Hanson, Kirsten K; Drewes, Gerard; Kocken, Clemens HM; Delves, Michael J; Leroy, Didier; Fidock, David A; Waterson, David; Street, Leslie J; Chibale, Kelly
A Malaria Transmission-Blocking (+)-Usnic Acid Derivative Prevents Plasmodium Zygote-to-Ookinete Maturation in the Mosquito Midgut. (2016)
Pastrana-Mena, Rebecca; Mathias, Derrick K; Delves, Michael; Rajaram, Krithika; King, Jonas G; Yee, Rebecca; Trucchi, Beatrice; Verotta, Luisella; Dinglasan, Rhoel R
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. (2016)
Van Voorhis, Wesley C; Adams, John H; Adelfio, Roberto; Ahyong, Vida; Akabas, Myles H; Alano, Pietro; Alday, Aintzane; Alemán Resto, Yesmalie; Alsibaee, Aishah; Alzualde, Ainhoa; Andrews, Katherine T; Avery, Simon V; Avery, Vicky M; Ayong, Lawrence; Baker, Mark; Baker, Stephen; Ben Mamoun, Choukri; Bhatia, Sangeeta; Bickle, Quentin; Bounaadja, Lotfi; Bowling, Tana; Bosch, Jürgen; Boucher, Lauren E; Boyom, Fabrice F; Brea, Jose; Brennan, Marian; Burton, Audrey; Caffrey, Conor R; Camarda, Grazia; Carrasquilla, Manuela; Carter, Dee; Belen Cassera, Maria; Chih-Chien Cheng, Ken; Chindaudomsate, Worathad; Chubb, Anthony; Colon, Beatrice L; Colón-López, Daisy D; Corbett, Yolanda; Crowther, Gregory J; Cowan, Noemi; D'Alessandro, Sarah; Le Dang, Na; Delves, Michael; DeRisi, Joseph L; Du, Alan Y; Duffy, Sandra; Abd El-Salam El-Sayed, Shimaa; Ferdig, Michael T; Fernández Robledo, José A; Fidock, David A; Florent, Isabelle; Fokou, Patrick VT; Galstian, Ani; Gamo, Francisco Javier; Gokool, Suzanne; Gold, Ben; Golub, Todd; Goldgof, Gregory M; Guha, Rajarshi; Guiguemde, W Armand; Gural, Nil; Guy, R Kiplin; Hansen, Michael AE; Hanson, Kirsten K; Hemphill, Andrew; Hooft van Huijsduijnen, Rob; Horii, Takaaki; Horrocks, Paul; Hughes, Tyler B; Huston, Christopher; Igarashi, Ikuo; Ingram-Sieber, Katrin; Itoe, Maurice A; Jadhav, Ajit; Naranuntarat Jensen, Amornrat; Jensen, Laran T; Jiang, Rays HY; Kaiser, Annette; Keiser, Jennifer; Ketas, Thomas; Kicka, Sebastien; Kim, Sunyoung; Kirk, Kiaran; Kumar, Vidya P; Kyle, Dennis E; Lafuente, Maria Jose; Landfear, Scott; Lee, Nathan; Lee, Sukjun; Lehane, Adele M; Li, Fengwu; Little, David; Liu, Liqiong; Llinás, Manuel; Loza, Maria I; Lubar, Aristea; Lucantoni, Leonardo; Lucet, Isabelle; Maes, Louis; Mancama, Dalu; Mansour, Nuha R; March, Sandra; McGowan, Sheena; Medina Vera, Iset; Meister, Stephan; Mercer, Luke; Mestres, Jordi; Mfopa, Alvine N; Misra, Raj N; Moon, Seunghyun; Moore, John P; Morais Rodrigues da Costa, Francielly; Müller, Joachim; Muriana, Arantza; Nakazawa Hewitt, Stephen; Nare, Bakela; Nathan, Carl; Narraidoo, Nathalie; Nawaratna, Sujeevi; Ojo, Kayode K; Ortiz, Diana; Panic, Gordana; Papadatos, George; Parapini, Silvia; Patra, Kailash; Pham, Ngoc; Prats, Sarah; Plouffe, David M; Poulsen, Sally-Ann; Pradhan, Anupam; Quevedo, Celia; Quinn, Ronald J; Rice, Christopher A; Abdo Rizk, Mohamed; Ruecker, Andrea; St Onge, Robert; Salgado Ferreira, Rafaela; Samra, Jasmeet; Robinett, Natalie G; Schlecht, Ulrich; Schmitt, Marjorie; Silva Villela, Filipe; Silvestrini, Francesco; Sinden, Robert; Smith, Dennis A; Soldati, Thierry; Spitzmüller, Andreas; Stamm, Serge Maximilian; Sullivan, David J; Sullivan, William; Suresh, Sundari; Suzuki, Brian M; Suzuki, Yo; Swamidass, S Joshua; Taramelli, Donatella; Tchokouaha, Lauve RY; Theron, Anjo; Thomas, David; Tonissen, Kathryn F; Townson, Simon; Tripathi, Abhai K; Trofimov, Valentin; Udenze, Kenneth O; Ullah, Imran; Vallieres, Cindy; Vigil, Edgar; Vinetz, Joseph M; Voong Vinh, Phat; Vu, Hoan; Watanabe, Nao-Aki; Weatherby, Kate; White, Pamela M; Wilks, Andrew F; Winzeler, Elizabeth A; Wojcik, Edward; Wree, Melanie; Wu, Wesley; Yokoyama, Naoaki; Zollo, Paul HA; Abla, Nada; Blasco, Benjamin; Burrows, Jeremy; Laleu, Benoît; Leroy, Didier; Spangenberg, Thomas; Wells, Timothy; Willis, Paul A
Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles. (2016)
Williamson, Alice E; Ylioja, Paul M; Robertson, Murray N; Antonova-Koch, Yevgeniya; Avery, Vicky; Baell, Jonathan B; Batchu, Harikrishna; Batra, Sanjay; Burrows, Jeremy N; Bhattacharyya, Soumya; Calderon, Felix; Charman, Susan A; Clark, Julie; Crespo, Benigno; Dean, Matin; Debbert, Stefan L; Delves, Michael; Dennis, Adelaide SM; Deroose, Frederik; Duffy, Sandra; Fletcher, Sabine; Giaever, Guri; Hallyburton, Irene; Gamo, Francisco-Javier; Gebbia, Marinella; Guy, R Kiplin; Hungerford, Zoe; Kirk, Kiaran; Lafuente-Monasterio, Maria J; Lee, Anna; Meister, Stephan; Nislow, Corey; Overington, John P; Papadatos, George; Patiny, Luc; Pham, James; Ralph, Stuart A; Ruecker, Andrea; Ryan, Eileen; Southan, Christopher; Srivastava, Kumkum; Swain, Chris; Tarnowski, Matthew J; Thomson, Patrick; Turner, Peter; Wallace, Iain M; Wells, Timothy NC; White, Karen; White, Laura; Willis, Paul; Winzeler, Elizabeth A; Wittlin, Sergio; Todd, Matthew H
2015
A novel multiple-stage antimalarial agent that inhibits protein synthesis. (2015)
Baragaña, Beatriz; Hallyburton, Irene; Lee, Marcus CS; Norcross, Neil R; Grimaldi, Raffaella; Otto, Thomas D; Proto, William R; Blagborough, Andrew M; Meister, Stephan; Wirjanata, Grennady; Ruecker, Andrea; Upton, Leanna M; Abraham, Tara S; Almeida, Mariana J; Pradhan, Anupam; Porzelle, Achim; Luksch, Torsten; Martínez, María Santos; Luksch, Torsten; Bolscher, Judith M; Woodland, Andrew; Norval, Suzanne; Zuccotto, Fabio; Thomas, John; Simeons, Frederick; Stojanovski, Laste; Osuna-Cabello, Maria; Brock, Paddy M; Churcher, Tom S; Sala, Katarzyna A; Zakutansky, Sara E; Jiménez-Díaz, María Belén; Sanz, Laura Maria; Riley, Jennifer; Basak, Rajshekhar; Campbell, Michael; Avery, Vicky M; Sauerwein, Robert W; Dechering, Koen J; Noviyanti, Rintis; Campo, Brice; Frearson, Julie A; Angulo-Barturen, Iñigo; Ferrer-Bazaga, Santiago; Gamo, Francisco Javier; Wyatt, Paul G; Leroy, Didier; Siegl, Peter; Delves, Michael J; Kyle, Dennis E; Wittlin, Sergio; Marfurt, Jutta; Price, Ric N; Sinden, Robert E; Winzeler, Elizabeth A; Charman, Susan A; Bebrevska, Lidiya; Gray, David W; Campbell, Simon; Fairlamb, Alan H; Willis, Paul A; Rayner, Julian C; Fidock, David A; Read, Kevin D; Gilbert, Ian H
Use of Plasmodium falciparum culture-adapted field isolates for in vitro exflagellation-blocking assay. (2015)
Leba, Louis-Jérôme; Musset, Lise; Pelleau, Stéphane; Estevez, Yannick; Birer, Caroline; Briolant, Sébastien; Witkowski, Benoit; Ménard, Didier; Delves, Michael J; Legrand, Eric; Duplais, Christophe; Popovici, Jean
Imaging-based high-throughput screening assay to identify new molecules with transmission-blocking potential against Plasmodium falciparum female gamete formation. (2015)
Miguel-Blanco, Celia; Lelièvre, Joël; Delves, Michael J; Bardera, Ana I; Presa, Jesús L; López-Barragán, María José; Ruecker, Andrea; Marques, Sara; Sinden, Robert E; Herreros, Esperanza
A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. (2015)
Phillips, Margaret A; Lotharius, Julie; Marsh, Kennan; White, John; Dayan, Anthony; White, Karen L; Njoroge, Jacqueline W; El Mazouni, Farah; Lao, Yanbin; Kokkonda, Sreekanth; Tomchick, Diana R; Deng, Xiaoyi; Laird, Trevor; Bhatia, Sangeeta N; March, Sandra; Ng, Caroline L; Fidock, David A; Wittlin, Sergio; Lafuente-Monasterio, Maria; Benito, Francisco Javier Gamo; Alonso, Laura Maria Sanz; Martinez, Maria Santos; Jimenez-Diaz, Maria Belen; Bazaga, Santiago Ferrer; Angulo-Barturen, Iñigo; Haselden, John N; Louttit, James; Cui, Yi; Sridhar, Arun; Zeeman, Anna-Marie; Kocken, Clemens; Sauerwein, Robert; Dechering, Koen; Avery, Vicky M; Duffy, Sandra; Delves, Michael; Sinden, Robert; Ruecker, Andrea; Wickham, Kristina S; Rochford, Rosemary; Gahagen, Janet; Iyer, Lalitha; Riccio, Ed; Mirsalis, Jon; Bathhurst, Ian; Rueckle, Thomas; Ding, Xavier; Campo, Brice; Leroy, Didier; Rogers, M John; Rathod, Pradipsinh K; Burrows, Jeremy N; Charman, Susan A
2014
Quantitative analysis of Plasmodium ookinete motion in three dimensions suggests a critical role for cell shape in the biomechanics of malaria parasite gliding motility. (2014)
Kan, Andrey; Tan, Yan-Hong; Angrisano, Fiona; Hanssen, Eric; Rogers, Kelly L; Whitehead, Lachlan; Mollard, Vanessa P; Cozijnsen, Anton; Delves, Michael J; Crawford, Simon; Sinden, Robert E; McFadden, Geoffrey I; Leckie, Christopher; Bailey, James; Baum, Jake
Changes in metabolic phenotypes of Plasmodium falciparum in vitro cultures during gametocyte development. (2014)
Lamour, Sabrina D; Straschil, Ursula; Saric, Jasmina; Delves, Michael J
Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans. (2014)
Malmquist, Nicholas A; Sundriyal, Sandeep; Caron, Joachim; Chen, Patty; Witkowski, Benoit; Menard, Didier; Suwanarusk, Rossarin; Renia, Laurent; Nosten, Francois; Jiménez-Díaz, María Belén; Angulo-Barturen, Iñigo; Santos Martínez, María; Ferrer, Santiago; Sanz, Laura M; Gamo, Francisco-Javier; Wittlin, Sergio; Duffy, Sandra; Avery, Vicky M; Ruecker, Andrea; Delves, Michael J; Sinden, Robert E; Fuchter, Matthew J; Scherf, Artur
An essential role of the basal body protein SAS-6 in Plasmodium male gamete development and malaria transmission. (2014)
Marques, Sara R; Ramakrishnan, Chandra; Carzaniga, Raffaella; Blagborough, Andrew M; Delves, Michael J; Talman, Arthur M; Sinden, Robert E
A male and female gametocyte functional viability assay to identify biologically relevant malaria transmission-blocking drugs. (2014)
Ruecker, A; Mathias, DK; Straschil, U; Churcher, TS; Dinglasan, RR; Leroy, D; Sinden, RE; Delves, MJ
The Plasmodium berghei sexual stage antigen PSOP12 induces anti-malarial transmission blocking immunity both in vivo and in vitro. (2014)
Sala, KA; Nishiura, H; Upton, LM; Zakutansky, SE; Delves, MJ; Iyori, M; Mizutani, M; Sinden, RE; Yoshida, S; Blagborough, AM
Lead clinical and preclinical antimalarial drugs can significantly reduce sporozoite transmission to vertebrate populations. (2014)
Upton, LM; Brock, PM; Churcher, TS; Ghani, AC; Gething, PW; Delves, MJ; Sala, KA; Leroy, D; Sinden, RE; Blagborough, AM
Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum. (2014)
Vaidya, Akhil B; Morrisey, Joanne M; Zhang, Zhongsheng; Das, Sudipta; Daly, Thomas M; Otto, Thomas D; Spillman, Natalie J; Wyvratt, Matthew; Siegl, Peter; Marfurt, Jutta; Wirjanata, Grennady; Sebayang, Boni F; Price, Ric N; Chatterjee, Arnab; Nagle, Advait; Stasiak, Marcin; Charman, Susan A; Angulo-Barturen, Iñigo; Ferrer, Santiago; Belén Jiménez-Díaz, María; Martínez, María Santos; Gamo, Francisco Javier; Avery, Vicky M; Ruecker, Andrea; Delves, Michael; Kirk, Kiaran; Berriman, Matthew; Kortagere, Sandhya; Burrows, Jeremy; Fan, Erkang; Bergman, Lawrence W
Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria. (2014)
White, Nicholas J; Ashley, Elizabeth A; Recht, Judith; Delves, Michael J; Ruecker, Andrea; Smithuis, Frank M; Eziefula, Alice C; Bousema, Teun; Drakeley, Chris; Chotivanich, Kesinee; Imwong, Mallika; Pukrittayakamee, Sasithon; Prachumsri, Jetsumon; Chu, Cindy; Andolina, Chiara; Bancone, Germana; Hien, Tran T; Mayxay, Mayfong; Taylor, Walter RJ; von Seidlein, Lorenz; Price, Ric N; Barnes, Karen I; Djimdé, Abdoulaye; ter Kuile, Feiko; Gosling, Roly; Chen, Ingrid; Dhorda, Mehul J; Stepniewska, Kasia; Guérin, Philippe; Woodrow, Charles J; Dondorp, Arjen M; Day, Nicholas PJ; Nosten, Francois H
2013
Assessing transmission blockade in Plasmodium spp. (2013)
Blagborough, Andrew M; Delves, Michael J; Ramakrishnan, Chandra; Lal, Kalpana; Butcher, Geoffrey; Sinden, Robert E
Male and female Plasmodium falciparum mature gametocytes show different responses to antimalarial drugs. (2013)
Delves, Michael J; Ruecker, Andrea; Straschil, Ursula; Lelièvre, Jöel; Marques, Sara; López-Barragán, María José; Herreros, Esperanza; Sinden, Robert E
Quinolone-3-diarylethers: a new class of antimalarial drug. (2013)
Nilsen, Aaron; LaCrue, Alexis N; White, Karen L; Forquer, Isaac P; Cross, Richard M; Marfurt, Jutta; Mather, Michael W; Delves, Michael J; Shackleford, David M; Saenz, Fabian E; Morrisey, Joanne M; Steuten, Jessica; Mutka, Tina; Li, Yuexin; Wirjanata, Grennady; Ryan, Eileen; Duffy, Sandra; Kelly, Jane Xu; Sebayang, Boni F; Zeeman, Anne-Marie; Noviyanti, Rintis; Sinden, Robert E; Kocken, Clemens HM; Price, Ric N; Avery, Vicky M; Angulo-Barturen, Iñigo; Jiménez-Díaz, María Belén; Ferrer, Santiago; Herreros, Esperanza; Sanz, Laura M; Gamo, Francisco-Javier; Bathurst, Ian; Burrows, Jeremy N; Siegl, Peter; Guy, R Kiplin; Winter, Rolf W; Vaidya, Akhil B; Charman, Susan A; Kyle, Dennis E; Manetsch, Roman; Riscoe, Michael K
Laboratory maintenance of rodent malaria parasites. (2013)
Ramakrishnan, Chandra; Delves, Michael J; Lal, Kalpana; Blagborough, Andrew M; Butcher, Geoffrey; Baker, Kenneth W; Sinden, Robert E
2012
Spatial localisation of actin filaments across developmental stages of the malaria parasite. (2012)
Angrisano, Fiona; Riglar, David T; Sturm, Angelika; Volz, Jennifer C; Delves, Michael J; Zuccala, Elizabeth S; Turnbull, Lynne; Dekiwadia, Chaitali; Olshina, Maya A; Marapana, Danushka S; Wong, Wilson; Mollard, Vanessa; Bradin, Clare H; Tonkin, Christopher J; Gunning, Peter W; Ralph, Stuart A; Whitchurch, Cynthia B; Sinden, Robert E; Cowman, Alan F; McFadden, Geoffrey I; Baum, Jake
Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria. (2012)
Biagini, Giancarlo A; Fisher, Nicholas; Shone, Alison E; Mubaraki, Murad A; Srivastava, Abhishek; Hill, Alisdair; Antoine, Thomas; Warman, Ashley J; Davies, Jill; Pidathala, Chandrakala; Amewu, Richard K; Leung, Suet C; Sharma, Raman; Gibbons, Peter; Hong, David W; Pacorel, Bénédicte; Lawrenson, Alexandre S; Charoensutthivarakul, Sitthivut; Taylor, Lee; Berger, Olivier; Mbekeani, Alison; Stocks, Paul A; Nixon, Gemma L; Chadwick, James; Hemingway, Janet; Delves, Michael J; Sinden, Robert E; Zeeman, Anne-Marie; Kocken, Clemens HM; Berry, Neil G; O'Neill, Paul M; Ward, Stephen A
Measuring the blockade of malaria transmission--an analysis of the Standard Membrane Feeding Assay. (2012)
Churcher, Thomas S; Blagborough, Andrew M; Delves, Michael; Ramakrishnan, Chandra; Kapulu, Melissa C; Williams, Andrew R; Biswas, Sumi; Da, Dari F; Cohuet, Anna; Sinden, Robert E
Plasmodium cell biology should inform strategies used in the development of antimalarial transmission-blocking drugs. (2012)
Delves, Michael J
A high-throughput assay for the identification of malarial transmission-blocking drugs and vaccines. (2012)
Delves, Michael J; Ramakrishnan, Chandra; Blagborough, Andrew M; Leroy, Didier; Wells, Timothy NC; Sinden, Robert E
The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites. (2012)
Delves, Michael; Plouffe, David; Scheurer, Christian; Meister, Stephan; Wittlin, Sergio; Winzeler, Elizabeth A; Sinden, Robert E; Leroy, Didier
The design and interpretation of laboratory assays measuring mosquito transmission of Plasmodium. (2012)
Sinden, Robert E; Blagborough, Andrew M; Churcher, Thomas; Ramakrishnan, Chandra; Biswas, Sumi; Delves, Michael J
2011
A GFP-actin reporter line to explore microfilament dynamics across the malaria parasite lifecycle. (2011)
Angrisano, Fiona; Delves, Michael J; Sturm, Angelika; Mollard, Vanessa; McFadden, Geoffrey I; Sinden, Robert E; Baum, Jake
Use of a selective inhibitor to define the chemotherapeutic potential of the plasmodial hexose transporter in different stages of the parasite's life cycle. (2011)
Slavic, Ksenija; Delves, Michael J; Prudêncio, Miguel; Talman, Arthur M; Straschil, Ursula; Derbyshire, Elvira T; Xu, Zhengyao; Sinden, Robert E; Mota, Maria M; Morin, Christophe; Tewari, Rita; Krishna, Sanjeev; Staines, Henry M